PENGARUH KADAR EUDRAGIT® S 100 TERHADAP KARAKTERISTIK FISIK MIKROPARTIKEL DAN EFEK IMUNOMODULATOR Bifidobacterium bifidum
Drug delivery system can be developed by microparticle system and microencapsulation used as the production method. Microencapsulation can protecting an active subtance from extreme condition and producing solid microparticles (1-1000 μm). In this study, pulsatile release used as release system,...
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| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | English Indonesian |
| Published: |
2016
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| Subjects: | |
| Online Access: | http://repository.unair.ac.id/57513/1/ABSTRACT.pdf http://repository.unair.ac.id/57513/13/57513.pdf http://repository.unair.ac.id/57513/ http://lib.unair.ac.id |
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| Institution: | Universitas Airlangga |
| Language: | English Indonesian |
| Summary: | Drug delivery system can be developed by microparticle system
and microencapsulation used as the production method. Microencapsulation
can protecting an active subtance from extreme condition and producing
solid microparticles (1-1000 μm). In this study, pulsatile release used as
release system, Eudragit® S 100 used as matrix and Bifidobacterium bifidum
used as the active substance. Bifidobacterium bifidum has
immunomodulatory effect in the intestine when the concentration is ≥ 106
cfu/ml but it is not stable in the gastric fluid. Mincroencapsulation method
in this study is spray dry because it is the common method in the probiotic
encapsulation. Three different Eudragit® S 100 concentrations, 0.5%; 1.0%;
and 1.5%, were named formula I, formula II, and formula III respectively
used as matrix of Bifidobacterium bifidum. Physical characteristic and
immunomodulatory were performed in all formula. The particle size of all
formula were variated in the range 2.265-9.060 μm. The moisture contain
showed in the formula I, formula II, formula II are 20.78±0.44 %, 8.99±2.09
%, and 8.83±0.39% respectively. The result of Microparticle morphology :
formula I is irregular shape and porous, formula II is spheris with few
concave surface, formula III is is spheris with more concave surface.
Formula I has the highest immunomadulatory effect which showed by the
highest hemaglutinine titer than other formula. |
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