POTENSI PEMBERIAN CURCUMIN PADA MENCIT BUNTING YANG DIINTOKSIKASI CADMIUM TERHADAP PERUBAHAN HISTOPATOLOGI HEPAR
Cadmium is one of heavy metal that caused disturbance to kind of organs. Liver is the main target of Cadmium Intoxication. The damage of the liver caused by oxidative stress which cause lipid peroxidation. Lipid peroxidation made changes in the cells that lead to death of the cells or necrosis. T...
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| Main Author: | |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | English Indonesian |
| Published: |
2016
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| Subjects: | |
| Online Access: | http://repository.unair.ac.id/60056/1/ABSTRACT%20KKC%20KK%20KH.%2025.17%20Dew%20p.pdf http://repository.unair.ac.id/60056/2/FULLTEXT%20KKC%20KK%20KH.%2025.17%20Dew%20p.pdf http://repository.unair.ac.id/60056/ http://lib.unair.ac.id |
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| Institution: | Universitas Airlangga |
| Language: | English Indonesian |
| Summary: | Cadmium is one of heavy metal that caused disturbance to kind of organs.
Liver is the main target of Cadmium Intoxication. The damage of the liver caused
by oxidative stress which cause lipid peroxidation. Lipid peroxidation made
changes in the cells that lead to death of the cells or necrosis. The purpose of this
study was to know the histopathological changes of liver through the amount of
total hepatocytes necrosis. Twenty Mus musculus divided into four different
groups. K0 as negative control group, K1 as positive control group which injected
by Cadmium 4,5mg/kgBW, K2 as the group that given Curcumin therapy
150mg/kgBW and K3 as the group that given Curcumin therapy 300mg/kgBW.
Day 17 all mice were sacrified for histopathological examination. The result of
the experiment get through examination of total hepatocytes necrosis from 500
hepatocytes that observed by light microscope with 400x magnification. The data
was analyzed by ANOVA and Honestly Significant Difference test (HSD/
Tukey). Result showed that the number of hepatocyte necrosis decreased in
compliance with the dose of Curcumin administration. The conclusion is
Curcumin can decrease the number of cell death and improve the quality of hepar
histopatology. |
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