PROTECTIVE EFFECT OF Spirulina platensis ON HISTOPATHOLOGICAL CHANGES OF RENAL CORTEX OF PHYSICAL-STRESSED RAT (Rattus norvegicus)

• Main Author: AISYAH SURYANINGRUM, 061211132048
• Format: Theses and Dissertations NonPeerReviewed
• Language: English; Indonesian
• Published: 2016
• Subjects: QL1-991 Zoology; QP501-801 Animal biochemistry
• Online Access: http://repository.unair.ac.id/60902/1/ABSTRACT%20KKC%20KK%20KH.%20167.17%20Sur%20p.pdf; http://repository.unair.ac.id/60902/2/FULLTEXT%20KKC%20KK%20KH.%20167.17%20Sur%20p.PDF; http://repository.unair.ac.id/60902/; http://lib.unair.ac.id
• Institution: Universitas Airlangga

This research aimed to determine the protective effect of Spirulina platensis on histopathological changes of renal cortex of physical-stressed rat (Rattus norvegicus). Twenty male rats were divided into five groups (C –, C +, T 1, T 2, T 3) and treated for 35 days. C – were administered 2 ml CMC-Na 0,5%, C + were treated excessive physical exercise (swimming) for one hour/day, T1 were administered 300 mg/kg bw Spirulina platensis extract + one hour of excessive physical exercise (swimming)/day, T2 were administered 600 mg/kg bw Spirulina platensis extract + one hour of excessive physical exercise (swimming)/day and T3 were administered 1200 mg/kg bw Spirulina platensis extract + one hour of excessive physical exercise (swimming)/day. The histopathological features of renal cortex were examined using Modified Klopfleisch Scoring method. The obtained data analyzed with Kruskal-Wallis test and Mann-Whitney test. The result showed that Spirulina platensis extract could protect histopathological changes of renal cortex of physical-stressed rat (Rattus norvegicus). The dose of 600 mg/kg bw Spirulina platensis extract could protect renal cortex of physical-stressed rat (Rattus norvegicus). The antioxidants of Spirulina platensis that scavenge the active radicals to suppress chain initiation and/or break the chain propagation reactions.