Foam-Cell Signified Blood Vessel Endhotel Repair and Histopatology of Abdominal Aorta through Stem Cell Allogenous Theraphy to Rats (Rattus norvegicus) with Atheroschlerosis
Atherosclerosis is a chronic inflammation process of endothel cell layer of blood vessels which is initiated by the disfunction of the endothel. This research aimed at understanding the repairment mechanism of the function of endothel in cardiac blood vessels with ateroskleroris case after being gi...
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| Main Authors: | , , , , |
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| Format: | Article PeerReviewed |
| Language: | English English |
| Published: |
International Journal of Epidemiology & Infection
2017
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| Subjects: | |
| Online Access: | http://repository.unair.ac.id/61378/1/Hening-peerreview1.FoamCell.pdf http://repository.unair.ac.id/61378/7/Abstrak.pdf http://repository.unair.ac.id/61378/ http://impactfactor.org/PDF/IJPCR/9/IJPCR,Vol9,Issue1,Article17.pdf |
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| Institution: | Universitas Airlangga |
| Language: | English English |
| Summary: | Atherosclerosis is a chronic inflammation process of endothel cell layer of blood vessels which is initiated by the disfunction of the endothel. This research aimed at understanding the repairment mechanism of the function of endothel in cardiac blood vessels with ateroskleroris case after being given medium-intenity physical exercises, mesenchymal stem cell and combination of the medium-intensity physical exercises and mesenchymal stem cell by lookin into the foam cell of abdominal aorta.
This research employed true experimental research design with post test only control group design. The sample of this reseach were 24 male Wistar rats (Rattus norvegicus) furrow that were controlled its homogenei
ty using inclusive criteria; confirming ateroclerosis, 20 week age, weight ranged from 180-200 gram, inhybrid, and healthy that were indicated by good desire for food and behaved normally. The Rattus norvegicus which fulfilled the inclusive criteria were divided into
three groups which first group was the control group (atheroscleoris rats).
The second group was ateroclerosis rats and received
regular medium-intensity physical exercises.
The third group atherosclerosis which received combination of regular medium-intensity physical exercises and received mesenchymal stem cell.
The result of manova test showed value p < 0.001 which indicated the existence of different foam cell found in the control group, exercise group, stem cell group and combined exercise and stem cell group. It can be concluded that attempt to decrease the risk factor of
aterosclerosis is one of the ways to protect the
endothel of the blood vessels. Deep understanding on this mechanism is expected to give new in sights to do preventive action and treatments toward ateroclerosis by combination theraphy of regular medium-intensity physical exercises and received mesenchymal stem cell. |
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