Enantioselective synthesis of axially chiral l-(naphthyl) isoquinolines and 2-(1-naphthyl)pyridines through sulfoxide ligand coupling reactions.

• Main Authors: W. Baker, Robert, O. Rea, Simon, V. Sargent, Melvyn, M.C.S., Elisabeth, Tjahjandarie, Tjitjik Srie, Totaro, Angela
• Format: Article PeerReviewed
• Language: English; English; English
• Published: Elsevier 2005
• Subjects: QD Chemistry
• Online Access: http://repository.unair.ac.id/61743/1/Cover.pdf; http://repository.unair.ac.id/61743/2/Bukti%20C02.%20Enantioselective%20synthesis%20of%20axially%20chiral%201-%28naphthyl%29%20isoquinolines%20and%20.........pdf; http://repository.unair.ac.id/61743/3/Bukti%20C02%20Peer%20reviewer%20dan%20validasi%20Kadep.pdf; http://repository.unair.ac.id/61743/; http://www.journals.elsevier.com/tetrahedron/editorial-board/
• Institution: Universitas Airlangga

Racemic 1-(1′-isoquinolinyl)-2-naphthalenemethanol rac-12 was prepared through a ligand coupling reaction of racemic 1-(tert-butylsulfinyl)isoquinoline rac-7 with the 1-naphthyl Grignard reagent 10. Resolution of rac-12 was achieved through chromatographic separation of the Noe-lactol derivatives 14...