PENGARUH EKSTRAK DAUN KITOLOD (Isotoma longiflora (L) Presl.) TERHADAP GAMBARAN HISTOPATOLOGI PENYEMBUHAN LUKA INSISI PADA MENCIT (Mus musculus)
This research’s aim is to find out the effect of Kitolod leaves’ extract in incision wound healing. This research consists of making incision wound on the mice’s back and cured by many treatments, K+ cured by Povidone Iodine 10% ointment, extract ointments which consist of 5%, 10%, and 20% concen...
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| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | Indonesian Indonesian |
| Published: |
2017
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| Subjects: | |
| Online Access: | http://repository.unair.ac.id/62388/1/KH.389.17%20.%20Ira.p%20-%20ABSTRAK.pdf http://repository.unair.ac.id/62388/2/KH.389.17%20.%20Ira.p%20-%20SEC.pdf http://repository.unair.ac.id/62388/ http://lib.unair.ac.id |
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| Institution: | Universitas Airlangga |
| Language: | Indonesian Indonesian |
| Summary: | This research’s aim is to find out the effect of Kitolod leaves’ extract in
incision wound healing. This research consists of making incision wound on the
mice’s back and cured by many treatments, K+ cured by Povidone Iodine 10%
ointment, extract ointments which consist of 5%, 10%, and 20% concentration for
6 days. The wound tissues were taken to observe the sum of fibroblast and fibrocyte
cells, and the collagen density. Histopathological exam was done and data analysis
for the sum of fibroblast and fibrocyte cells used ANNOVA followed with Duncan
test, while scoring of collagen density used Kruskal-Wallis Test followed with
Mann Whitney Test. Analysis of the sum of fibroblast and fibrocyte cells showed
K+ has mean and standard deviation 406,4 ± 78,96, K- 277,4 ± 69,16, P1 252,0 ±
8,66, P2 356,6 ± 49,76, and P3 269,6 ± 65,91. Analysis of the collagen density
showed K+ has mean and standard deviation 24,0 ± 2,44, K- 15,2 ± 5,89, P1 18,4
± 2,60, P2 23,8 ± 1,92, and P3 18,2 ± 2,94. The results showed there was significant
difference between K+ to all treatments except P2 (p< 0,05) both the sum of
fibroblast and fibrocyte cells, and the collagen density, but insignificance different
between K+ and P2 . The increase of the fibroblast and fibrocyte cells, and the
collagen density can strengthen the wound. The conclusion of these research was
10% of Kitolod leaves’ extract ointment can accelerate wound healing process by
increasing the number of fibroblast and fibrocyte cells, and the collagen density. |
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