PENGARUH SUPLEMENTASI PROBIOTIK DAN VITAMIN B1, B6, B12 TERHADAP PERUBAHAN KADAR IFN-γ DAN IL-12 PADA PASIEN TUBERKULOSIS DENGAN OBAT ANTI TUBERKULOSIS KATEGORI 1
Tuberculosis is an acute infectious disease that primarily affects the lungs. Probiotic supplementation proved to increase the number and activity of NK cell in peripheral blood by immunomodulation by IL-12, thus can increase IFN- γ production by Th1 response. Vitamin B1 acts on macrophages and a...
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| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | English English |
| Published: |
2017
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| Subjects: | |
| Online Access: | http://repository.unair.ac.id/63943/1/abstrak.pdf http://repository.unair.ac.id/63943/2/RAHMAWATI%20RAISING%20051415153011%20-%20PENGARUH%20SUPLEMENTASI%20PROBIOTIK%20DAN%20VITAMIN%20B1%20B6%20B12%20%20IFN%20DAN%20IL12%20%282%29.pdf http://repository.unair.ac.id/63943/ |
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| Institution: | Universitas Airlangga |
| Language: | English English |
| Summary: | Tuberculosis is an acute infectious disease that primarily affects the lungs.
Probiotic supplementation proved to increase the number and activity of NK cell in
peripheral blood by immunomodulation by IL-12, thus can increase IFN- γ production by
Th1 response. Vitamin B1 acts on macrophages and affects neutrophil motility. Vitamin B6
is associated with the release of cytokines and the responsiveness of NK cells, vitamin B12
affects to lymphocytes, T cell proliferation, CD4+ ratios, and NK cell activity.
Objectives: This study aimed to analyze the effects of probiotics and vitamin B1, B6, B12
suplementation on IFN-γ and IL-12 levels in patients with TB infection during intensive
phase therapy.
Methods: This study was conducted on December 2016 to February 2017 at Universitas
Airlangga Hospital and Community Health Centers in Surabaya. Patients were divided into
two groups standard regimen group and treatment group with once daily supplementation
of probiotics and vitamin B1, B6, B12. Primary outcomes were measured plasma IFN-γ and
IL-12 levels before initiation of study, after one month and two months after treatment.
Results: 22 patients were divided into two groups. Plasma IFN-γ levels in the control
(p=0.445) and treatment group (p=0.241) increased in first month then decreased after
second months. Plasma IL-12 levels in control (p=0.091) and treatment group (p=0.061)
increased in first month then decreased after second months.
Conclusion: Therapy of probiotics and vitamin B1, B6, B12 suplementation tend to increase
plasma IFN-γ and IL-12 levels in the first month and decrease in the second month |
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