STUDI PENGGUNAAN OBAT ANTI TUBERKULOSIS (OAT) PADA PASIEN TUBERKULOSIS EKSTRA PARU (Penelitian dilakukan di RSUD Dr. Soetomo Surabaya)
Tuberculosis (TB) is infectious disease caused by Mycobacterium Tuberculosis which mostly (80%) attacks the lungs but also can infect other body organs such as the pleura, lymph nodes, abdomen, intestines, urinary tract, kidneys, genitals, skin, meningitis, pericardium, bone and joints, referred...
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| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | Indonesian Indonesian |
| Published: |
2017
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| Subjects: | |
| Online Access: | http://repository.unair.ac.id/64960/1/FF%20FK%2035-17%20Fit%20s%20Abstrak.pdf http://repository.unair.ac.id/64960/2/FF%20FK%2035-17%20Fit%20s%20Sec.pdf http://repository.unair.ac.id/64960/ http://lib.unair.ac.id |
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| Institution: | Universitas Airlangga |
| Language: | Indonesian Indonesian |
| Summary: | Tuberculosis (TB) is infectious disease caused by Mycobacterium
Tuberculosis which mostly (80%) attacks the lungs but also can infect
other body organs such as the pleura, lymph nodes, abdomen, intestines,
urinary tract, kidneys, genitals, skin, meningitis, pericardium, bone and
joints, referred to extrapulmonary TB. Therefore, the aim of this study
was to review the use of antituberculosis drugs (OAT) in patient with
extrapulmonary TB at Poli TB RSUD Dr. Soetomo Surabaya and identify
drug related problem (DRP) that may occur. It was a retrospective
observational descriptive study using time limited sampling conducted
from January 2014 to October 2016. The inclusion criteria was medical
record of adult extrapulmonary TB patient (18-65 years old) with
complete treatment and/or additional diagnosis which had been given
OAT as therapy.
The results showed that from 48 patients, the most common sites
of extrapulmonary TB were lymph nodes (N=23). The most widely used
regimen in intensive phase was HRZE (combination of isoniazid,
rifampicin, pyrazinamide, ethambutol) and in continuation phase was HR
(combination of isoniazid and rifampicin) (67%). OAT-FDC Category 1
was the most often given to patients with appropriated the route and
frequency of administration. While some patients with weight gain,
allergic, drug induced hepatitis (DIH), complication and kidney function
deterioration required types, combinations, and OAT dose adjustment.
Most patient underwent therapy for up to 12 until 14 months (40%). Two
types of DRP identified in this study were actual adverse drug reactions
and potential drug interactions. |
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