STUDI AKTIVITAS ANTI-HCV TERHADAP VIRUS JFH1a PADA TANAMAN DARI SUKU LAURACEAE YANG TUMBUH DI KEBUN RAYA BALIKPAPAN, KALIMANTAN TIMUR
Eusideroxylon zwageri, Alseodaphne elmeri, and Neolitsea cassiaefolia are plants from Lauraceae family. Previous research reported that several compounds showed hepatitis C activity such as terpenoids, flavonoids, and alkaloids. These plants then gradually extracted using hexane, dichloromethane...
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| Main Author: | |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | Indonesian English |
| Published: |
2017
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| Subjects: | |
| Online Access: | http://repository.unair.ac.id/65126/1/FF.FT.21.17%20.%20Azm.s%20-%20ABSTRAK.pdf http://repository.unair.ac.id/65126/2/FF.FT.21.17%20.%20Azm.s%20-%20SEC.pdf http://repository.unair.ac.id/65126/ http://lib.unair.ac.id |
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| Institution: | Universitas Airlangga |
| Language: | Indonesian English |
| Summary: | Eusideroxylon zwageri, Alseodaphne elmeri, and Neolitsea
cassiaefolia are plants from Lauraceae family. Previous research reported
that several compounds showed hepatitis C activity such as terpenoids,
flavonoids, and alkaloids. These plants then gradually extracted using
hexane, dichloromethane, and methanol solvent and screened for
antihepatitis C virus activity using JFH1a infected in Huh7it cell culture
system and cytotoxicity assay using Huh7it cell. The results showed that
dichloromethane extract of N. cassiaefolia leaves has the highest inhibition
percentage 92,90% ± 3,86%. Cytotoxic assay result showed the percentage
of cell viability from the dicloromethane extract of Neolitsea cassiaefolia
leaves 64,655 ± 7,315% compare to control. Further separation of
dichloromethane extract of Neolitsea cassiaefolia leaves using Thin Layer
Chromatography showed purple spot that indicate terpenoid substances. In
conclusion dichloromethane extract of Neolitsea cassiaefolia leaves
contained terpenoid and has the highest activity against HCV. |
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