PROFIL KADAR INTERFERON GAMMA INDUCED PROTEIN 10 (IP 10) SERUM PADA PASIEN KUSTA BORDERLINE DENGAN DAN TANPA REAKSI KUSTA TIPE 1
Leprosy reaction is an acute episode in leprosy characterized by acute inflammation sometimes accompanied with systemic symptoms. Leprosy type 1 reaction often occurs in borderline leprosy patients. Leprosy type 1 reaction can cause peripheral nerve damage through neuritis that can lead to disabi...
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id-langga.651582017-10-30T20:24:58Z http://repository.unair.ac.id/65158/ PROFIL KADAR INTERFERON GAMMA INDUCED PROTEIN 10 (IP 10) SERUM PADA PASIEN KUSTA BORDERLINE DENGAN DAN TANPA REAKSI KUSTA TIPE 1 Agustina Tri Pujiastuti, NIM011180408 RL Dermatology Leprosy reaction is an acute episode in leprosy characterized by acute inflammation sometimes accompanied with systemic symptoms. Leprosy type 1 reaction often occurs in borderline leprosy patients. Leprosy type 1 reaction can cause peripheral nerve damage through neuritis that can lead to disability. Interferon-γ induced protein 10 (IP10) is a chemokine with chemotaxis function to various immune cells such as macrophage, dendritic cells, Natural Killer cells, and activated T lymphocites. Several studies have found an increase of IP10 serum level when type 1 reaction occurred. Purpose: To evaluate the profile of IP10 serum levels in borderline patients with and without type 1 leprosy reaction. Method: This is a descriptive cross-sectional study, with 34 borderline leprosy patients of which 17 had leprosy type 1 reaction and 17 without reaction that qualify inclusion and exclusion criteria. Results: Mean serum IP10 levels in leprosy type 1 reaction groups are 594,123±327,628 pg/mL and 331,648±101,819 pg/mL in groups without reaction. Conclusions: Serum IP10 levels in borderline leprosy patient is higher than patients without reaction, although confounding factors in borderline leprosy patients with type 1 reaction that can influence serum IP10 levels cannot be eliminated. Need further studies to reveal the role of IP`10 in type 1 leprosy reaction. 2017-10-31 Thesis NonPeerReviewed text en http://repository.unair.ac.id/65158/1/abstrak.pdf text en http://repository.unair.ac.id/65158/2/KA_Agustina%20Tri%20Pujiastutik%2C%20dr_%20NIM%20011180408.compressed.pdf Agustina Tri Pujiastuti, NIM011180408 (2017) PROFIL KADAR INTERFERON GAMMA INDUCED PROTEIN 10 (IP 10) SERUM PADA PASIEN KUSTA BORDERLINE DENGAN DAN TANPA REAKSI KUSTA TIPE 1. Thesis thesis, Universitas Airlangga. |
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RL Dermatology Agustina Tri Pujiastuti, NIM011180408 PROFIL KADAR INTERFERON GAMMA INDUCED PROTEIN 10 (IP 10) SERUM PADA PASIEN KUSTA BORDERLINE DENGAN DAN TANPA REAKSI KUSTA TIPE 1 |
description |
Leprosy reaction is an acute episode in leprosy characterized by
acute inflammation sometimes accompanied with systemic symptoms. Leprosy
type 1 reaction often occurs in borderline leprosy patients. Leprosy type 1 reaction
can cause peripheral nerve damage through neuritis that can lead to disability.
Interferon-γ induced protein 10 (IP10) is a chemokine with chemotaxis function to
various immune cells such as macrophage, dendritic cells, Natural Killer cells,
and activated T lymphocites. Several studies have found an increase of IP10
serum level when type 1 reaction occurred.
Purpose: To evaluate the profile of IP10 serum levels in borderline patients with
and without type 1 leprosy reaction.
Method: This is a descriptive cross-sectional study, with 34 borderline leprosy
patients of which 17 had leprosy type 1 reaction and 17 without reaction that
qualify inclusion and exclusion criteria.
Results: Mean serum IP10 levels in leprosy type 1 reaction groups are
594,123±327,628 pg/mL and 331,648±101,819 pg/mL in groups without reaction.
Conclusions: Serum IP10 levels in borderline leprosy patient is higher than
patients without reaction, although confounding factors in borderline leprosy
patients with type 1 reaction that can influence serum IP10 levels cannot be
eliminated. Need further studies to reveal the role of IP`10 in type 1 leprosy
reaction. |
format |
Theses and Dissertations NonPeerReviewed |
author |
Agustina Tri Pujiastuti, NIM011180408 |
author_facet |
Agustina Tri Pujiastuti, NIM011180408 |
author_sort |
Agustina Tri Pujiastuti, NIM011180408 |
title |
PROFIL KADAR INTERFERON GAMMA INDUCED
PROTEIN 10 (IP 10) SERUM
PADA PASIEN KUSTA BORDERLINE
DENGAN DAN TANPA REAKSI KUSTA TIPE 1 |
title_short |
PROFIL KADAR INTERFERON GAMMA INDUCED
PROTEIN 10 (IP 10) SERUM
PADA PASIEN KUSTA BORDERLINE
DENGAN DAN TANPA REAKSI KUSTA TIPE 1 |
title_full |
PROFIL KADAR INTERFERON GAMMA INDUCED
PROTEIN 10 (IP 10) SERUM
PADA PASIEN KUSTA BORDERLINE
DENGAN DAN TANPA REAKSI KUSTA TIPE 1 |
title_fullStr |
PROFIL KADAR INTERFERON GAMMA INDUCED
PROTEIN 10 (IP 10) SERUM
PADA PASIEN KUSTA BORDERLINE
DENGAN DAN TANPA REAKSI KUSTA TIPE 1 |
title_full_unstemmed |
PROFIL KADAR INTERFERON GAMMA INDUCED
PROTEIN 10 (IP 10) SERUM
PADA PASIEN KUSTA BORDERLINE
DENGAN DAN TANPA REAKSI KUSTA TIPE 1 |
title_sort |
profil kadar interferon gamma induced
protein 10 (ip 10) serum
pada pasien kusta borderline
dengan dan tanpa reaksi kusta tipe 1 |
publishDate |
2017 |
url |
http://repository.unair.ac.id/65158/1/abstrak.pdf http://repository.unair.ac.id/65158/2/KA_Agustina%20Tri%20Pujiastutik%2C%20dr_%20NIM%20011180408.compressed.pdf http://repository.unair.ac.id/65158/ |
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1681148881287512064 |