UJI AKTIVITAS ANTASIDA DAN ANTIFLATULEN DARI EKSTRAK ETANOL 70% KENINGAR (Cinnamomum zeylanicum Blume) DALAM SEDIAAN SIRUP SECARA IN VITRO

• Main Author: FITRIA AFIFATUL MUFIDAH, 051311133040
• Format: Theses and Dissertations NonPeerReviewed
• Language: Indonesian; Indonesian
• Published: 2017
• Subjects: RS Pharmacy and materia medica
• Online Access: http://repository.unair.ac.id/65188/1/FF.FT.36.17%20.%20Mut.u%20-%20ABSTRAK.pdf; http://repository.unair.ac.id/65188/2/FF.FT.36.17%20.%20Mut.u%20-%20SEC.pdf; http://repository.unair.ac.id/65188/; http://lib.unair.ac.id
• Institution: Universitas Airlangga

Gastric ulcer is one of gastrointestinal disorders that affects many people in the World. Antacids have been used for years to treat gastric ulcer, but they can cause several side effects, such as diarrhea, constipation, metabolic alkalosis, hypercalcemia, and renal insufficiency. Cinnamomum zeylanicum Blume is a medicinal plant traditionally used in the treatment of gastrointestinal disorders. The aims of this study are to evaluate the neutralizing time and defoaming action of 70% ethanolic extract of C. zeylanicum in syrup using artificial stomach models. In this study, aluminum hydroxide-magnesium hydroxide combination and dimethylpolysiloxane were used as positive control for antacid and antiflatulent assays, respectively. Non-medicated syrup was used as negative control, and the 70% ethanolic extract of C. zeylanicum at concentration of 1%, 2%, and 3% were used as test samples. The results of neutralizing time evaluation showed that the 70% ethanolic extract of C. zeylanicum at concentration of 1%, 2%, and 3% neutralized artificial gastric acid within 73 minutes, 24 minutes, and 7 minutes, respectively. The results of defoaming action evaluation showed that dimethylpolysiloxane had defoaming action in 20 minutes. The 70% ethanolic extract of C. zeylanicum at concentration of 1%, 2%, and 3% reduced foam height to1.0 ± 0.1 cm, 1.6 ± 0.1 cm, and 1.8 ± 0.1 cm, respectively, in 20 minutes. Although the results of antacid and antiflatulent assays of extracts and control negative are statistically showed significant difference, it can be concluded that extract of C. zeylanicum in syrup has weak antacid and antiflatulent activities.