PENGARUH GUGUS NITRO TERHADAP WAKTU SINTESIS 2,3 DIFENILKUINAZOLIN-4(3H)-ON 3-(4-NITROFENIL)-2-FENILKUINAZOLIN-4(3H)-ON DENGAN BANTUAN IRADIASI GELOMBANG MIKRO

• Main Author: PANDITYA PURNAYA, 051311133155
• Format: Theses and Dissertations NonPeerReviewed
• Language: Indonesian; Indonesian
• Published: 2017
• Subjects: RS Pharmacy and materia medica
• Online Access: http://repository.unair.ac.id/65247/1/FF.KF.23.17%20.%20Pur.p%20-%20ABSTRAK.pdf; http://repository.unair.ac.id/65247/2/FF.KF.23.17%20.%20Pur.p%20-%20SEC.pdf; http://repository.unair.ac.id/65247/; http://lib.unair.ac.id
• Institution: Universitas Airlangga

This study aims to synthesize between 3-(4-nitrophenyl)-2- phenylquinazolin-4(3H)-on and 2,3-diphenylquinazolin-4(3H)-one The reaction between 2-phnyl-4H-benzo[d][1,3]oxazin-4-one with aniline gave 3-(4-nitrophenyl)-2-phenylquinazolin-4(3H)-one, while the reaction between 4- hydroxybenzohyd2-phenyl-4Hbenzo[ d][1,3]oxazin-4-one and p-nitroaniline gave 3-(4-2,3- diphenylquinazolin-4(3H)-one,. The synthesize were completed by microwave irradiation N-phenyl-2-benzamidobenzamide was obtained as amorphous, lightweight, and white crystal with 96% percentage yield and 20 minutes reaction, while 3-(4-nitrophenyl)-2- phenylquinazolin-4(3H)-one,was obtained as lightweight and colorless needles with 58% percentage yield and 30 minutes s. The structure of resulted compound were confirmed by UV- Vis spectrophotometer, IR spectrophotometer and 1H-NMR spectrometer. It was concluded that nitro group responsible to increase time of completing reaction in the synthesize of 23-(4- nitrophenyl)-2-phenylquinazolin-4(3H)-one. The time of completing reaction 3-(4-nitrophenyl)-2-phenylquinazolin-4(3H)-one was higher than the time of completing reaction of N-phenyl-2- benzamidobenzamide