PENGARUH PENAMBAHAN HPMC TERHADAP AKSEPTABILITAS DAN PENETRASI COENZYME Q10 YANG DIBUAT DALAM SISTEM NANOSTRUCTURED LIPID CARRIER (Melalui membran kulit tikus)
The aim of this study was to investigate the capabilty of nanostructured lipid carriers gel deliver Ubiquinone compared to nanostructured lipid carriers(NLC) through the rat skin. In this study, Nile red was used as a fluorescence label in NLC and NLCs gel . This study was executed by applying s...
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| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | Indonesian Indonesian |
| Published: |
2017
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| Subjects: | |
| Online Access: | http://repository.unair.ac.id/65496/1/FF%20F%2036-17%20Ift%20p%20Abstrak.pdf http://repository.unair.ac.id/65496/2/FF%20F%2036-17%20Ift%20p%20Sec.pdf http://repository.unair.ac.id/65496/ http://lib.unair.ac.id |
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| Institution: | Universitas Airlangga |
| Language: | Indonesian Indonesian |
| Summary: | The aim of this study was to investigate the capabilty of nanostructured
lipid carriers gel deliver Ubiquinone compared to nanostructured lipid
carriers(NLC) through the rat skin. In this study, Nile red was used as a
fluorescence label in NLC and NLCs gel . This study was executed by
applying sample test on rat skin in vivo during 2 and 4.5 hours. The
interaction between fluorescence labeled, NLC, and NLC gel and rat skin
was observed by fluorescence microscopy.
After 4.5 hours, NLC and NLC Gel were penetrated into deeper dermis
layer compared to the second hour. Meanwhile,NLC Gel also can
penetrated deeper than NLC in both of 2 and 4,5 hours. This could be due
to smaller particle size and higher occlusion that can make deeper
penetration of Ubiquinone into the rat skin. The acceptability test was used
3 parameters, such as greasy feels on the skin, calmng sensation , and
absorption time on skin. This test shows that Ubiquinone NLC more
acceptable than Ubiquinone NLC Gel. |
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