PENGARUH PERBEDAAN METODE PEMBUATAN NANOSTRUCTURED LIPID CARRIER (NLC) YANG DIBUAT DENGAN METODE HOT HOMOGENIZATION DAN COLD HOMOGENIZATION TERHADAP KARAKTERISTIK NLC-CoQ10
Coenzyme Q10 (CoQ10) or ubiquinone has antioxidant effect. CoQ10 is unstable compound and easily degraded by light. Nanostructured Lipid Carriers (NLC) is the one commonly used delivery system to protect unstable compound. NLC has been introduced as the second generation of lipid nanoparticle. T...
Saved in:
Main Author: | |
---|---|
Format: | Theses and Dissertations NonPeerReviewed |
Language: | Indonesian Indonesian |
Published: |
2017
|
Subjects: | |
Online Access: | http://repository.unair.ac.id/65497/1/FF%20F%2037-17%20Han%20p%20Abstrak.pdf http://repository.unair.ac.id/65497/2/FF%20F%2037-17%20Han%20p%20Sec.pdf http://repository.unair.ac.id/65497/ http://lib.unair.ac.id |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Universitas Airlangga |
Language: | Indonesian Indonesian |
id |
id-langga.65497 |
---|---|
record_format |
dspace |
spelling |
id-langga.654972017-12-28T16:34:20Z http://repository.unair.ac.id/65497/ PENGARUH PERBEDAAN METODE PEMBUATAN NANOSTRUCTURED LIPID CARRIER (NLC) YANG DIBUAT DENGAN METODE HOT HOMOGENIZATION DAN COLD HOMOGENIZATION TERHADAP KARAKTERISTIK NLC-CoQ10 IZZATU AL HANIFIYAH, 051311133198 RS1-441 Pharmacy and materia medica Coenzyme Q10 (CoQ10) or ubiquinone has antioxidant effect. CoQ10 is unstable compound and easily degraded by light. Nanostructured Lipid Carriers (NLC) is the one commonly used delivery system to protect unstable compound. NLC has been introduced as the second generation of lipid nanoparticle. The first generation of lipid nanoparticle is Solid Lipid Nanoparticle (SLN). The main difference between SLN and NLC was performed by nanostructuring the lipid matrix, in order to decrease the particle size and increase the entrapment efficiency. NLC also has some advantages such as give more modulation of drug release, increase drug loading and prevent its leakage. The factors that affecting the characteristics of NLC are the composition of materials and method of preparation. The aim of this study was to identify the characteristic of CoQ10 loaded NLC with different preparation method. There are many preparation method can be done in making NLC. In this study NLC were prepared with hot homogenization and cold homogenization by using high shear homogenization method at 24000 rpm for 2 minutes and 15000 rpm for 1 minutes, and performed for 4 cycles. The product were characterized for particle size and entrapment efficiency (%EE). The result showed cold homogenization method has smaller particle size (123 nm) than hot homogenization method (254,6 nm). But, different preparation method has not effect on the entrapment efficiency (%EE). 2017 Thesis NonPeerReviewed text id http://repository.unair.ac.id/65497/1/FF%20F%2037-17%20Han%20p%20Abstrak.pdf text id http://repository.unair.ac.id/65497/2/FF%20F%2037-17%20Han%20p%20Sec.pdf IZZATU AL HANIFIYAH, 051311133198 (2017) PENGARUH PERBEDAAN METODE PEMBUATAN NANOSTRUCTURED LIPID CARRIER (NLC) YANG DIBUAT DENGAN METODE HOT HOMOGENIZATION DAN COLD HOMOGENIZATION TERHADAP KARAKTERISTIK NLC-CoQ10. Skripsi thesis, Universitas Airlangga. http://lib.unair.ac.id |
institution |
Universitas Airlangga |
building |
Universitas Airlangga Library |
country |
Indonesia |
collection |
UNAIR Repository |
language |
Indonesian Indonesian |
topic |
RS1-441 Pharmacy and materia medica |
spellingShingle |
RS1-441 Pharmacy and materia medica IZZATU AL HANIFIYAH, 051311133198 PENGARUH PERBEDAAN METODE PEMBUATAN NANOSTRUCTURED LIPID CARRIER (NLC) YANG DIBUAT DENGAN METODE HOT HOMOGENIZATION DAN COLD HOMOGENIZATION TERHADAP KARAKTERISTIK NLC-CoQ10 |
description |
Coenzyme Q10 (CoQ10) or ubiquinone has antioxidant effect.
CoQ10 is unstable compound and easily degraded by light. Nanostructured
Lipid Carriers (NLC) is the one commonly used delivery system to
protect unstable compound. NLC has been introduced as the second
generation of lipid nanoparticle. The first generation of lipid nanoparticle
is Solid Lipid Nanoparticle (SLN). The main difference between SLN and
NLC was performed by nanostructuring the lipid matrix, in order to
decrease the particle size and increase the entrapment efficiency. NLC
also has some advantages such as give more modulation of drug release,
increase drug loading and prevent its leakage. The factors that affecting
the characteristics of NLC are the composition of materials and method of
preparation. The aim of this study was to identify the characteristic of
CoQ10 loaded NLC with different preparation method. There are many
preparation method can be done in making NLC. In this study NLC were
prepared with hot homogenization and cold homogenization by using
high shear homogenization method at 24000 rpm for 2 minutes and 15000
rpm for 1 minutes, and performed for 4 cycles. The product were
characterized for particle size and entrapment efficiency (%EE). The
result showed cold homogenization method has smaller particle size (123
nm) than hot homogenization method (254,6 nm). But, different
preparation method has not effect on the entrapment efficiency (%EE). |
format |
Theses and Dissertations NonPeerReviewed |
author |
IZZATU AL HANIFIYAH, 051311133198 |
author_facet |
IZZATU AL HANIFIYAH, 051311133198 |
author_sort |
IZZATU AL HANIFIYAH, 051311133198 |
title |
PENGARUH PERBEDAAN METODE PEMBUATAN NANOSTRUCTURED LIPID CARRIER (NLC) YANG DIBUAT DENGAN METODE HOT HOMOGENIZATION DAN COLD HOMOGENIZATION TERHADAP KARAKTERISTIK NLC-CoQ10 |
title_short |
PENGARUH PERBEDAAN METODE PEMBUATAN NANOSTRUCTURED LIPID CARRIER (NLC) YANG DIBUAT DENGAN METODE HOT HOMOGENIZATION DAN COLD HOMOGENIZATION TERHADAP KARAKTERISTIK NLC-CoQ10 |
title_full |
PENGARUH PERBEDAAN METODE PEMBUATAN NANOSTRUCTURED LIPID CARRIER (NLC) YANG DIBUAT DENGAN METODE HOT HOMOGENIZATION DAN COLD HOMOGENIZATION TERHADAP KARAKTERISTIK NLC-CoQ10 |
title_fullStr |
PENGARUH PERBEDAAN METODE PEMBUATAN NANOSTRUCTURED LIPID CARRIER (NLC) YANG DIBUAT DENGAN METODE HOT HOMOGENIZATION DAN COLD HOMOGENIZATION TERHADAP KARAKTERISTIK NLC-CoQ10 |
title_full_unstemmed |
PENGARUH PERBEDAAN METODE PEMBUATAN NANOSTRUCTURED LIPID CARRIER (NLC) YANG DIBUAT DENGAN METODE HOT HOMOGENIZATION DAN COLD HOMOGENIZATION TERHADAP KARAKTERISTIK NLC-CoQ10 |
title_sort |
pengaruh perbedaan metode pembuatan nanostructured lipid carrier (nlc) yang dibuat dengan metode hot homogenization dan cold homogenization terhadap karakteristik nlc-coq10 |
publishDate |
2017 |
url |
http://repository.unair.ac.id/65497/1/FF%20F%2037-17%20Han%20p%20Abstrak.pdf http://repository.unair.ac.id/65497/2/FF%20F%2037-17%20Han%20p%20Sec.pdf http://repository.unair.ac.id/65497/ http://lib.unair.ac.id |
_version_ |
1681148939393302528 |