PENGARUH VANADIL SULFAT TERHADAP PROLIFERASI SEL β PANKREAS PADA MENCIT DIABETES YANG DIINDUKSI STREPTOZOTOCIN PENELITIAN EKSPERIMENTAL LABORATORIS

This study aimed to determine the effects of vanadyl sulfate to stimulate proliferation of pancreatic β cells and characterized by an increased number of islet of Langerhans, β cell number and the number of Ki-67 expression. DM animal model was done by using male BALB/C mice induced by streptozot...

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Main Author: Khoirotin nisak, 051414153004
Format: Theses and Dissertations NonPeerReviewed
Language:English
English
Published: 2017
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Online Access:http://repository.unair.ac.id/66411/1/abstrak.pdf
http://repository.unair.ac.id/66411/2/thesis%20full.compressed.pdf
http://repository.unair.ac.id/66411/
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Institution: Universitas Airlangga
Language: English
English
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spelling id-langga.664112017-11-12T23:40:04Z http://repository.unair.ac.id/66411/ PENGARUH VANADIL SULFAT TERHADAP PROLIFERASI SEL β PANKREAS PADA MENCIT DIABETES YANG DIINDUKSI STREPTOZOTOCIN PENELITIAN EKSPERIMENTAL LABORATORIS Khoirotin nisak, 051414153004 RS Pharmacy and materia medica This study aimed to determine the effects of vanadyl sulfate to stimulate proliferation of pancreatic β cells and characterized by an increased number of islet of Langerhans, β cell number and the number of Ki-67 expression. DM animal model was done by using male BALB/C mice induced by streptozotocin (ip) dose of 100 mg/kgBW followed by 50 mg/kgBW. DM achieved when blood glucose levels> 300 mg / dL. Animals were then grouped into 5 groups: normal group, DM group, and treatment group of vanadyl sulfate (po) dose of 5 mg/kgBW, 30 mg/kgBW, or 100 mg/kgBW (n = 6) for 7 days. Animal then sacrificed, stained, and scored by Allred method. Statistical result by using One- Way Anova showed that there is significant differences in blood glucose levels (p = 0,0129), only between normal group and DM group. There is no significant difference for the number of islet of Langerhans between groups. For the number of β cells showed there is significant difference (p <0,05) between groups with an increase in the number of β cells along with increasing doses of vanadyl sulfat. While the number of Ki-67 expression showed no significant difference between groups. it can be conclude that vanadyl sulfate may improve pancreatic β cell proliferation, but without an increase in the number of islets of Langerhans and increased expression of Ki-67. The mechanism of how the proliferation of pancreatic β cells still needed a further research 2017-11-13 Thesis NonPeerReviewed text en http://repository.unair.ac.id/66411/1/abstrak.pdf text en http://repository.unair.ac.id/66411/2/thesis%20full.compressed.pdf Khoirotin nisak, 051414153004 (2017) PENGARUH VANADIL SULFAT TERHADAP PROLIFERASI SEL β PANKREAS PADA MENCIT DIABETES YANG DIINDUKSI STREPTOZOTOCIN PENELITIAN EKSPERIMENTAL LABORATORIS. Thesis thesis, Universitas Airlangga.
institution Universitas Airlangga
building Universitas Airlangga Library
country Indonesia
collection UNAIR Repository
language English
English
topic RS Pharmacy and materia medica
spellingShingle RS Pharmacy and materia medica
Khoirotin nisak, 051414153004
PENGARUH VANADIL SULFAT TERHADAP PROLIFERASI SEL β PANKREAS PADA MENCIT DIABETES YANG DIINDUKSI STREPTOZOTOCIN PENELITIAN EKSPERIMENTAL LABORATORIS
description This study aimed to determine the effects of vanadyl sulfate to stimulate proliferation of pancreatic β cells and characterized by an increased number of islet of Langerhans, β cell number and the number of Ki-67 expression. DM animal model was done by using male BALB/C mice induced by streptozotocin (ip) dose of 100 mg/kgBW followed by 50 mg/kgBW. DM achieved when blood glucose levels> 300 mg / dL. Animals were then grouped into 5 groups: normal group, DM group, and treatment group of vanadyl sulfate (po) dose of 5 mg/kgBW, 30 mg/kgBW, or 100 mg/kgBW (n = 6) for 7 days. Animal then sacrificed, stained, and scored by Allred method. Statistical result by using One- Way Anova showed that there is significant differences in blood glucose levels (p = 0,0129), only between normal group and DM group. There is no significant difference for the number of islet of Langerhans between groups. For the number of β cells showed there is significant difference (p <0,05) between groups with an increase in the number of β cells along with increasing doses of vanadyl sulfat. While the number of Ki-67 expression showed no significant difference between groups. it can be conclude that vanadyl sulfate may improve pancreatic β cell proliferation, but without an increase in the number of islets of Langerhans and increased expression of Ki-67. The mechanism of how the proliferation of pancreatic β cells still needed a further research
format Theses and Dissertations
NonPeerReviewed
author Khoirotin nisak, 051414153004
author_facet Khoirotin nisak, 051414153004
author_sort Khoirotin nisak, 051414153004
title PENGARUH VANADIL SULFAT TERHADAP PROLIFERASI SEL β PANKREAS PADA MENCIT DIABETES YANG DIINDUKSI STREPTOZOTOCIN PENELITIAN EKSPERIMENTAL LABORATORIS
title_short PENGARUH VANADIL SULFAT TERHADAP PROLIFERASI SEL β PANKREAS PADA MENCIT DIABETES YANG DIINDUKSI STREPTOZOTOCIN PENELITIAN EKSPERIMENTAL LABORATORIS
title_full PENGARUH VANADIL SULFAT TERHADAP PROLIFERASI SEL β PANKREAS PADA MENCIT DIABETES YANG DIINDUKSI STREPTOZOTOCIN PENELITIAN EKSPERIMENTAL LABORATORIS
title_fullStr PENGARUH VANADIL SULFAT TERHADAP PROLIFERASI SEL β PANKREAS PADA MENCIT DIABETES YANG DIINDUKSI STREPTOZOTOCIN PENELITIAN EKSPERIMENTAL LABORATORIS
title_full_unstemmed PENGARUH VANADIL SULFAT TERHADAP PROLIFERASI SEL β PANKREAS PADA MENCIT DIABETES YANG DIINDUKSI STREPTOZOTOCIN PENELITIAN EKSPERIMENTAL LABORATORIS
title_sort pengaruh vanadil sulfat terhadap proliferasi sel β pankreas pada mencit diabetes yang diinduksi streptozotocin penelitian eksperimental laboratoris
publishDate 2017
url http://repository.unair.ac.id/66411/1/abstrak.pdf
http://repository.unair.ac.id/66411/2/thesis%20full.compressed.pdf
http://repository.unair.ac.id/66411/
_version_ 1681149094372835328