STUDI AKTIVITAS ANTI-HCV TERHADAP VIRUS JFH1a PADA TANAMAN MELICOPE GLABRA DAN LUVUNGA SCANDENS YANG TUMBUH DI HUTAN KONSERVASI BALIKPAPAN, KALIMANTAN TIMUR

• Main Author: ROSYIDA PARAMITHA, 051311133136
• Format: Theses and Dissertations NonPeerReviewed
• Language: Indonesian; Indonesian
• Published: 2017
• Subjects: RM Therapeutics. Pharmacology; RS1-441 Pharmacy and materia medica
• Online Access: http://repository.unair.ac.id/66456/1/FF.FT.%2052-17%20Par%20s%20abstrak.pdf; http://repository.unair.ac.id/66456/2/FF.FT.%2052-17%20Par%20s%20fulltext.pdf; http://repository.unair.ac.id/66456/; http://lib.unair.ac.id
• Institution: Universitas Airlangga

Hepatitis C has been reported as a major health problem that cause liver cirrhosis which can lead to hepatocellular carcinoma and death. The combination therapy of pegylated interferon alfa (PEG-IFNα) with ribavirin has limited benefits due to its significant side effects and high cost. Medicinal plants provide unlimited opportunities as a new drugs for treatment of HCV because of its great substances. In previous study, Ruta angustifolia from Rutaceae family showed a potential activity against J6/JFH1 virus on hepatocyte cell Huh7it. Melicope glabra and Luvunga scandens were chosen by chemotaxonomy method because they are from Rutaceae family. Hexane, dicloromethane, and methanol were used to extract the leaves and stembarks of Melicope glabra and Luvunga scandens. The result showed that the hexane and dicloromethane extract of Luvunga scandens leaves have potential activity in inhibiting the viral infection of cells with IC50 value 4.08 μg/ml and 14.15 μg/ml respectively. Phytochemical screening using thin layer chromatography of active extract showed that it contained the compounds known as alkaloids, terpenoids, and flavonoids. Further studies of compounds that have anti-hepatitis C activity are needed.