STUDI AKTIVITAS ANTIMALARIA SECARA IN VITRO TERHADAP PLASMODIUM FALCIPARUM PADA TANAMAN DARI SUKU LAURACEAE YANG TUMBUH DI KEBUN RAYA BALIKPAPAN, KALIMANTAN TIMUR

• Main Author: RIZA ROSITA MURIYANI, 051311133168
• Format: Theses and Dissertations NonPeerReviewed
• Language: Indonesian; Indonesian
• Published: 2017
• Subjects: RC31-1245 Internal medicine; RC554-569.5 Personality disorders. Behavior problems Including sexual problems, drug abuse,suicide, child abuse; RM Therapeutics. Pharmacology
• Online Access: http://repository.unair.ac.id/66457/1/FF.FT.%2055-17%20Mur%20s%20abstrak.pdf; http://repository.unair.ac.id/66457/2/FF.FT.%2055-17%20Mur%20s%20fulltext.pdf; http://repository.unair.ac.id/66457/; http://lib.unair.ac.id
• Institution: Universitas Airlangga

Malaria is an infectious disease that caused by parasites of the Plasmodium family. Severe malaria is mainly caused by Plasmodium falciparum. The presence of resistance Plasmodiumparasite against antimalarial drugs, encourages the discovery of new chemical compounds for antimalarial agent.Exploration of medicinal plants from Balikpapan Botanical Garden has obtained Eusideroxylon zwageri, Alseodaphne elmeriandNeolitseacassiaefolia from Lauraceae family.These plants were extracted using n-hexane, dicloromethane, and methanol solvents gradually. Phytochemical screening was undertaken by TLC method on the extracts to investigate the presence of alkaloid, flavonoid, terpenoid, polifenol and antrakuinon. Antimalarial screening was performed by using ELISA-HRP II and microscopic. The results indicated that the DCM extract of Neolitsea cassiaefolia foliumshowed the highest inhibition in both ELISA-HRP II and microscopic methods with % inhibition of (73,93±1,34%) and (99,6±0,60%) respectively. The result of phytochemical screening suggested that DCM extract of Neolitseacassiaefolia folium contained terpenoid.