HUBUNGAN PENURUNAN KADAR CD4 DENGAN POLA KEPEKAAN MYCOBACTERIUM TUBERCULOSIS TERHADAP RIFAMPISIN PADA PASIEN KO-INFEKSI TB-HIV DI RSUD DR. SOETOMO SURABAYA

• Main Author: Firsta Wahono Febrianto, NIM011411131022
• Format: Theses and Dissertations NonPeerReviewed
• Language: English; Indonesian
• Published: 2017
• Subjects: RC306-320.5 Tuberculosis
• Online Access: http://repository.unair.ac.id/68446/1/FK%20PD%20357-17%20Feb%20h%20Abstrak.pdf; http://repository.unair.ac.id/68446/2/FK%20PD%20357-17%20Feb%20h%20Sec.pdf; http://repository.unair.ac.id/68446/; http://lib.unair.ac.id
• Institution: Universitas Airlangga

Background: Rifampicin-resistance Tuberculosis (TB) case rate is increasing every year, particularly in Indonesia. It is probably caused by the infection of Human Immunodeficiency Virus (HIV) on Tuberculosis patient, called TB-HIV co-infection. However, the association between HIV infection, which can cause decreasing of CD4, and Rifampicin-resistance Mycobacterium tuberculosis in TB-HIV co-infection patients is still not clearly yet. Objective: This study was undertaken to describe the demographics profile of TB-HIV co-infection patients and analyze the association between CD4 decreasing and Rifampicin resistance in TB-HIV co-infection patients of Dr. Soetomo General Hospital Surabaya. Methods: A retrospective research with cross-sectional method of TB-HIV co-infection patients’ medical record at Medical Record Center of Dr. Soetomo General Hospital Surabaya from 1 January to 31 December 2016 with 40 samples. Result: TB-HIV co-infection was common in male (70%). It was dominated by the productive age between 25-44 years old (55%). Most of them were high school graduated (80%) and 52,5% of them had been married. Rifampicin-sensitive Mycobacterium tuberculosis was still the most found (86%). Chi Square test shows that there is no association (p=0,545) between CD4 decreasing and Rifampicin-resistance Mycobacterium tuberculosis in TB-HIV co-infection patients of Dr. Soetomo General Hospital Surabaya. Conclusion: TB-HIV co-infection was common in male, productive age, high school graduated, and married patients. Rifampicin-sensitive Mycobacterium tuberculosis was still the most found and there is no association between CD4 decreasing and Rifampicin-resistance Mycobacterium tuberculosis in TB-HIV co-infection patients.