PENGARUH PEMBERIAN EKSTRAK DAUN KELOR (Moringa oleifera)TERHADAP EKSPRESI IGF-1, RESEPTOR ANDROGEN DAN KETEBALAN ENDOMETRIUM PADA TIKUS BETINA MODEL SINDROMA OVARIUM POLIKISTIK DENGAN RESISTENSI INSULIN

• Main Author: IIN SETIAWATI, NIM011514653009
• Format: Theses and Dissertations NonPeerReviewed
• Language: Indonesian; Indonesian
• Published: 2017
• Subjects: RC554-569.5 Personality disorders. Behavior problems Including sexual problems, drug abuse,suicide, child abuse
• Online Access: http://repository.unair.ac.id/68657/1/TKR.%2028%20-%2017%20Set%20p%20abstrak.pdf; http://repository.unair.ac.id/68657/2/TKR.%2028%20-%2017%20Set%20p%20fulltext.pdf; http://repository.unair.ac.id/68657/; http://lib.unair.ac.id
• Institution: Universitas Airlangga

PCOS was a frequent problem of reproductive endocrinology. Women with PCOS have an increased rwask of a number of gynecological neoplasms including endometrial cancer. It was expected that extract leaf Moringa oleifera can decrease the expression of IGF-1, Expression of Androgen reseptors and endometrial thickness. The aim of thwas study was to prove the effect of extract leaf Moringa oleifera in various doses on expression of IGF-1, expression of androgen receptors and endometrial thickness in model PCOS with insulin reswastance. Thwas research method used sample 40 female rattus norvegicus strains wwastar age 3 months with weight 100-130 gram. Then divided into 5 groups conswasting of normal control group, PCOS control group, Metformin group , leaf extract Moringa oleifera group 250 mg/ KgBW and 500 mg/ KgBW. Measurements of IGF-1 expression and expression of androgen receptors with immunohwastochemwastry (IHC) and endometrial thickness with hematoxyn eosin (HE). The results showed that the metformin group and extract leaf Moringa oleifera 250 mg/ KgBW decreased IGF-1 expression significantly (p<0.05) compared with PCOS control group, metformin group and leaf extract Moringa oleifera 250 mg/ KgBW showed significantly decreased expression of androgen receptor (p <0.05) compared with PCOS control group and leaf extract group of Moringa oleifera 250 mg/ KgBW significantly decreased the thickness of endometrium (p <0.05) compared with PCOS control group, with significant dose in leaf extract Moringa oleifera 250 mg/ KgBW. The conclusion of thwas study was leaf extract Moringa oleifera can decrease the expression of IGF-1, and expression of androgen receptor so that it can also decrease the thickness of endometrium in model PCOS.