ANALISIS PENGGUNAAN ANTIBIOTIKA TERHADAP POLA RESISTENSI ISOLAT FLORA USUS ESCHERICHIA COLI (Penelitian Dilakukan pada Pasien Penyakit Dalam dan Bedah Dewasa RS Aisyiyah Bojonegoro)
The prudent use of antibiotics is essential for optimizing efficacy, minimizing adverse effects, and also minimizing the risk of resistance and maintaining the value of the existence of an antibiotic class The purpose of this study are (1) knowing the pattern of antibiotic use in patients with in...
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Format: | Theses and Dissertations NonPeerReviewed |
Language: | Indonesian Indonesian |
Published: |
2018
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Subjects: | |
Online Access: | http://repository.unair.ac.id/70488/1/ABSTRACT.pdf http://repository.unair.ac.id/70488/2/TFK%2005-18%20Hid%20a.pdf http://repository.unair.ac.id/70488/ http://lib.unair.ac.id |
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Institution: | Universitas Airlangga |
Language: | Indonesian Indonesian |
Summary: | The prudent use of antibiotics is essential for optimizing efficacy,
minimizing adverse effects, and also minimizing the risk of resistance and
maintaining the value of the existence of an antibiotic class The purpose of this
study are (1) knowing the pattern of antibiotic use in patients with internal and
surgical case in Aisyiyah Bojonegoro Hospital, (2) knowing the resistance pattern
of intestinal isolate flora Escherichia coli when exit from Aisyiyah Bojonegoro
Hospital, and also (3) analyzing the effect of antibiotic use to resistance pattern of
intestinal isolate flora Escherichia coli.
The study population was all hospitalized adult patient with internal and
surgical case at Aisyiyah Bojonegoro Hospital from June until Oktober 2017
periode, with a total sampling technique that is 101 person. From the analysis it
can be concluded that: (1) based on the results of t-test, there was a significant
effect between using antibiotics on E. coli resistance to antibiotics, including
cefotaxime (p = 0.046), ceftazidime (p = 0.046), ceftriaxone (p = 0.017),
aztreonam (p = 0.024) and cefepime (p = 0.010); (2) the results of regression
analysis (t test) also proved that there was a significant positive influence between
the quantity of antibitotic use (in DDD) on E. coli resistance to antibiotics test of
cefepime (p = 0.003), cefepime (p = 0.000) and ciprofloxacin (p = 0.014),
cefotaxone (p = 0.010), ceftazidime (p = 0.010); (3) the results of multivariate
logistic regression analysis proved that there was a simultaneous influence
between the type of service and DDD antibiotics on the antibiotic test of (p =
0.002), cefepime (p = 0.002), ciprofloxacin (p = 0.031), and meropenem (p =
0.004), cefepime (p = 0.001), cefotaxime (p = 0.013). Based on the these result
test it is necessary to prepare the guidelines for the use of wise antibiotics to the
resistance pattern and its implementation for the progress of pharmacy service at
Aisyiyah Bojonegoro hospital. |
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