ANALISIS PENGARUH PEMBERIAN SIMVASTATIN TERHADAP KADAR SERUM INTERLEUKIN-6 (IL-6) PADA PASIEN STROKE ISKEMIK AKUT (Penelitian dilakukan di IRNA Medik Ilmu Penyakit Saraf RSUD Dr. Soetomo Surabaya dan Rumah Sakit Universitas Airlangga Surabaya)
Background: Acute ischemic stroke is the leading cause of death and the cause of permanent disability in adults worldwide. In acute ischemic stroke, there is an increase in IL-6 levels that were correlated with more severe neurological deficits, more extensive brain damage and worse prognoses. An...
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| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | Indonesian Indonesian |
| Published: |
2018
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| Subjects: | |
| Online Access: | http://repository.unair.ac.id/70517/1/ABSTRACT%20.pdf http://repository.unair.ac.id/70517/2/TFK%2007-18%20Meo%20a.pdf http://repository.unair.ac.id/70517/ http://lib.unair.ac.id |
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| Institution: | Universitas Airlangga |
| Language: | Indonesian Indonesian |
| Summary: | Background: Acute ischemic stroke is the leading cause of death and the cause of
permanent disability in adults worldwide. In acute ischemic stroke, there is an increase in
IL-6 levels that were correlated with more severe neurological deficits, more extensive
brain damage and worse prognoses. An updated meta-analysis indicated that prestroke
statin use was associated with milder initial stroke severity, better functional outcome and
lower mortality
Objectives: To analyze the difference of serum IL-6 levels between the group of acute
ischemic stroke patients treated with Simvastatin 20 mg and the ischemic stroke patients in
placebo group.
Methods: . Samples were taken using consecutive sampling method from hospitalized
acute ischemic stroke patients in Neurology Department of Dr. Soetomo Teaching Hospital
Surabaya and Airlangga University Hospital Surabaya from August to November 2017.
Results: Total of 44 patients met the inclusion criteria, consisting of 22 patients in
treatment group and 22 patients in control group. There were no significant difference in
the characteristic of the patients in both groups (p>0.05). Averages of serum IL-6 in the
control and the treatment group are 38.594±74.313 and 17.760±25.253 (p=0,438) while
averages of serum IL-6 post in the control group and the treatment are 46.586±103.484 and
15.275±17.183 (p=0,589). There were no significant level escalation in pre and post of
control group (p = 0.205) and also no significant level reduction in pre and post of
treatment group (p = 0.411), while the average difference in the control group (-7.992 +
78.912 pg/ml) and in the treatment group (2.485 + 23.738 pg/ml).
Conclusion: Simvastatin 20 mg was not significantly decreases IL-6 serum level in the
acute ischemic stroke patients. |
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