PROFIL KADAR ANTIBODI ANTI PHENOLIC GLYCOLIPID-1 (PGL-1) PADA NARAKONTAK SERUMAH PASIEN KUSTA DI RSUD DR. SOETOMO SURABAYA
Background: Leprosy is a chronic infection caused by Mycobacterium leprae. It is still a challenging health problem in Indonesia with many new cases each year found in big city such as Surabaya. Leprosy occurs more commonly among household contacts. High titer of specific M. Leprae antibody found...
Saved in:
| Main Author: | |
|---|---|
| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | Indonesian Indonesian |
| Published: |
2017
|
| Subjects: | |
| Online Access: | http://repository.unair.ac.id/70807/1/PPDS.IKK.%2005-18%20Ros%20p%20Abstrak.pdf http://repository.unair.ac.id/70807/2/PPDS.IKK.%2005-18%20Ros%20p.pdf http://repository.unair.ac.id/70807/ http://lib.unair.ac.id |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Universitas Airlangga |
| Language: | Indonesian Indonesian |
| Summary: | Background: Leprosy is a chronic infection caused by Mycobacterium leprae. It
is still a challenging health problem in Indonesia with many new cases each year
found in big city such as Surabaya. Leprosy occurs more commonly among
household contacts. High titer of specific M. Leprae antibody found in blood
without clinical symptoms is considered as subclinical leprosy. Early detection of
this state plays an important role in elimination goal.
Objective: to evaluate anti-PGL-1 antibody profiles in household contacts of
multibacillary patients undergoing observation in Department of Dermatology and
Venereology, Soetomo General Hospital- Surabaya.
Materials and methods: We observed 62 household contacts of new patients and
or within 3 months therapy. Blood were collected using filter paper and IgM anti-
PGL-1 antibody were examined using ELISA.
Results: Eighteen contacts (29%) tested positive for anti-PGL-1 antibodies with
an average of 942,4±390,6 u/mL. The number of contacts based on the
seropositivity rate was 17.7% for +1 and 11.3% for +2. Seropositive female was
22,6% and age-group of 18-36 years equal to 9.7%. Duration of contact-group of
6-16 years was 9,7%. Consanguinity with the patients was determined for 22,6%.
Occupants more than 4 person in the household was 17.7% (973.9±428.2 u/ml).
Conclusions: Household contacts at risk of developing clinical leprosy tend to
have these characteristics : female, productive age, long-term contact, and inhabit
crowded area. |
|---|