PERBANDINGAN JUMLAH KOLONI BAKTERI PADA HUMOR AKUOS DAN VITREUS ANTARA TERAPI MOXIFLOXACIN INTRAVITREAL DENGAN TERAPI KOMBINASI MOXIFLOXACIN DAN DEXAMETHASONE INTRAVITREAL PADA ENDOFTALMITIS STAPHYLOCOCCUS AUREUS (Studi Eksperimental pada Oryctolagus cuniculus)
Purpose: To evaluate the difference of aqueous and vitreous in colony forming units (CFU/ml) between intravitreal moxifloxacin and moxifloxacin-dexamethasone combination in an experimental rabbit model of Staphylococcus aureus endophthalmitis. Methods: The right eyes of 18 rabbits weighing 2 to...
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Format: | Theses and Dissertations NonPeerReviewed |
Language: | Indonesian Indonesian |
Published: |
2018
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Subjects: | |
Online Access: | http://repository.unair.ac.id/71520/1/PPDS.IKM.%2009-18%20Ros%20p%20Abstrak.pdf http://repository.unair.ac.id/71520/2/PPDS.IKM.%2009-18%20Ros%20p.pdf http://repository.unair.ac.id/71520/ http://lib.unair.ac.id |
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Institution: | Universitas Airlangga |
Language: | Indonesian Indonesian |
Summary: | Purpose: To evaluate the difference of aqueous and vitreous in colony forming units
(CFU/ml) between intravitreal moxifloxacin and moxifloxacin-dexamethasone
combination in an experimental rabbit model of Staphylococcus aureus
endophthalmitis.
Methods: The right eyes of 18 rabbits weighing 2 to 4 kg were used. 102 colony
forming units of S. aureus in 0.1 ml saline solution were inoculated into the vitreous
cavity. The eyes were randomly assigned into three groups equally. Twenty four
hours after the inoculation of S. aureus, claimed with positive clinical appearance
and gram staining from vitreous aspiration, group 1 received 0.1ml Balanced Salt
Solution (BSS) as control, group 2 received 60 μg moxifloxacin, group 3 received
60 μg moxifloxacin plus 400 μg dexamethasone. The eyes were enucleated for
aqueous and vitreous aspirates for microbiological analysis. Statistical analysis was
performed using Oneway Anova, Kruskal-Wallis and Mann-Whitney U tests.
Results: In all treatment groups, mean number of aqueous were significantly lower
compared with control group p = 0.000 (p < 0.05). In all treatment groups, median
vitreous score were significantly lower compared with control group p = 0.003 (p
< 0.05). The control in aqueous group had a statistically difference number of CFU
compared with moxifloxacin p = 0.000 (p < 0.05) and moxifloxacin plus
dexamethasone p = 0.000 (p < 0.05). The moxifloxacin in aquos group had
significant difference of CFU compared with moxifloxacin dexamethasone
combination p = 0.028 (p < 0.05). The control in vitreous group had significant
difference of CFU compared with moxifloxacin p = 0.004 (p < 0.05) and in
moxifloxacin plus dexamethasone p = 0.006 (p < 0.05). The moxifloxacin in
vitreous group had no significant difference of CFU compared with moxifloxacin
dexamethasone combination p = 0.201 (p < 0.05).
Conclusions: Bacteriological outcomes after treatment using moxifloxacin and
moxifloxacin-dexamethasone combination were comparable. There were lower
number of CFU in aqueous and vitreous in moxifloxacin compared with
moxifloxacin dexamethasone combination. Intravitreal moxifloxacin alone may be
an option in the treatment of S. aureus endophthalmitis. |
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