HUBUNGAN ANTARA TINGKAT PENGETAHUAN DENGAN WABAH HEPATITIS A DI LAMONGAN DAN BANGKALAN TAHUN 2018

• Main Author: DEWI SETYOWATI, NIM011714253012
• Format: Theses and Dissertations NonPeerReviewed
• Language: Indonesian; Indonesian
• Published: 2018
• Subjects: RC31-1245 Internal medicine
• Online Access: http://repository.unair.ac.id/74724/1/TKT.%2006-18%20Set%20h%20Abstrak.pdf; http://repository.unair.ac.id/74724/2/TKT.%2006-18%20Set%20h.pdf; http://repository.unair.ac.id/74724/; http://lib.unair.ac.id
• Institution: Universitas Airlangga

Background: Hepatitis A virus (HAV) is an important causative agent of acute hepatitis in humans worldwide. Its transmission occurs fecal orally from personto- person contact and from the consumption of contaminated water and food. The incidence of hepatitis A varies greatly from country to country and is associated with socioeconomic factors that impact the quality of sanitation. Many factors caused infection of hepatitis A, such as knowledge. Aims: The aim of this study was to describe an outbreak of acute hepatitis in Lamongan and Bangkalan, East java in 2018 and to correlate knowledge with infection of Hepatitis A on this outbreak. Material and methods: In this study, 88 HAV suspected cases were analysed by Rapid Test Diagnostic for the presence of antibodies to HAV. All of serum was extracted. Samples found positive by RT-PCR and nested RT-PCR using primers targeting the VP1-P2A junction and VP1-VP3 capsid region of HAV, were subjected to sequencing and phylogenetic analyses. To assess the knowledge by questionnaire. Results: IgM type antibodies to HAV were detected in 51 (58%) person. Phylogenetic analysis showed that the majority of HAV strains detected in this study belong to the “HAV 1A” cluster. Analysis of the relationship of knowledge level on hepatitis A prevention with the incidence of hepatitis A infection among subjects in this study showed no relationship (p> 0,05) in Bangkalan, but the result showed relationship in Lamongan and combine of both region (p<0,05). Conclusions: Sub-genotype IA is the most prevalent genotype in Indonesia. Analysis of the relationship of knowledge level on hepatitis A prevention with the incidence of hepatitis A infection among subjects in this study showed no relationship (p> 0,05) in Bangkalan, but the result showed a relationship in Lamongan and combination of both region (p<0,05).