SINTESIS TURUNAN DIALKILAMINOMETIL PINOSTROBIN (BASA MANNICH) DENGAN MENGGUNAKAN IRADIASI GELOMBANG MIKRO
This research was conducted to synthesize the derivatives of dialkylaminomethylpinostrobin as the target compound by using Mannich reaction to enhance bioactivity of pinostrobin. The synthesis using microwave irradiation was done in one pot reaction. The product was then purified by column chrom...
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| Main Author: | |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | Indonesian Indonesian |
| Published: |
2018
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| Subjects: | |
| Online Access: | http://repository.unair.ac.id/75249/1/TF.%2025-18%20Sum%20s%20Abstrak.pdf http://repository.unair.ac.id/75249/2/TF.%2025-18%20Sum%20s.pdf http://repository.unair.ac.id/75249/ http://lib.unair.ac.id |
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| Institution: | Universitas Airlangga |
| Language: | Indonesian Indonesian |
| Summary: | This research was conducted to synthesize the derivatives of
dialkylaminomethylpinostrobin as the target compound by using Mannich
reaction to enhance bioactivity of pinostrobin. The synthesis using microwave
irradiation was done in one pot reaction. The product was then purified by column
chromatography to give purified products, which were analysed using IR, 1HNMR,
13C-NMR and mass spectroscopy to determine their structures, and it was
concluded that the obtained compounds were 6-(4-methylpiperazine-1-
ylmethyl)pinostrobin in 63,64% yield, 6-(piperidin-1-ilmetil)pinostrobin in
12,14% yield, 6-[(N,N-dibutilamino)metil]pinostrobin in 24,97% yield, 6-
(morfolin-1-ilmetil)pinostrobin in 74,30% yield and 6-[(N,N-dietilamino)metil]-
pinostrobin in 19,40% yield. |
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