Preparation and Solid State Characterization of Binary Mixtures of Acyclovir – Succinic Acid

• Main Authors: Winantari, Agnes Nuniek, Setyawan, Dwi, Siswandono, Siswandono, Soewandhi, Sundani Nurono
• Format: Article PeerReviewed
• Language: English; English
• Published: Sai scientific communications 2017
• Subjects: RS Pharmacy and materia medica; RS1-441 Pharmacy and materia medica; RS200-201 Pharmaceutical dosage forms
• Online Access: http://repository.unair.ac.id/75750/1/C-19%20Artikel.pdf; http://repository.unair.ac.id/75750/2/C-19%20Validasi%20dan%20Peer%20Reviewer.pdf; http://repository.unair.ac.id/75750/
• Institution: Universitas Airlangga

Physical interaction of acyclovir – succinic acid (AS) was studied. The aim of this study is to prepare and characterize binary mixture of AS. Methods of cocrystallization was solvent evaporation in equimolar ratio between acyclovir and succinic acid using ethanol and methanol. The cocrystals were characterized by Differential Scanning Calorimetry (DSC), Powder X-Ray Diffraction (PXRD), and Fourier Transform Infra Red (FTIR) spectroscopy. Physical characterization showed a new endothermic peak at 175.36 o C according to DSC analysis. The PXRD patterns of AS binary mixture after cocrystallization are different from pure components. Furthermore, specific peaks was found at 2θ = 24,77 o , 35,88 o and 37,99 o (AS in ethanol); 19,99 o and 21,01 o (AS in methanol). In addition, there are a shift in the O-H, N-H and C=O spectrum of FTIR.