UJI EFEKTIVITAS PELET ALENDRONAT YANG DICROSSLINK DENGAN GLUTARALDEHID PADA CELAH TULANG AKIBAT FRAKTUR KARENA OSTEOPOROSIS
Osteoporosis is a bone disorder that is characterized by decreasing the density and strength of bone, disruption of bone architecture that may result in fracture. Osteoporosis occurs when there is an increase in bone resorption process that is far beyond the ability of osteoblast form new bone....
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id-langga.768742018-12-17T11:29:10Z http://repository.unair.ac.id/76874/ UJI EFEKTIVITAS PELET ALENDRONAT YANG DICROSSLINK DENGAN GLUTARALDEHID PADA CELAH TULANG AKIBAT FRAKTUR KARENA OSTEOPOROSIS FITROTIN AULIYAH, 051311133119 RD701-811 Orthopedic surgery RM300-666 Drugs and their actions Osteoporosis is a bone disorder that is characterized by decreasing the density and strength of bone, disruption of bone architecture that may result in fracture. Osteoporosis occurs when there is an increase in bone resorption process that is far beyond the ability of osteoblast form new bone. Esterogen deficiency is one of events that can cause osteoporosis. The objective of this research was to determine the effectiveness of pellet alendronate which is crosslinked by glutaraldehyde for the defect of fracture that caused by osteoporosis. The rats were ovariectomized on the 8th day after were adapted for 7 days, then drilling on the femur was 2.2 mm and then treated according to the group (Give pellet or not). After that, terminate them to take the femur at 6th week after drilling. Then, performed observation on the defect either radiologically and Haematoxylin-Eosin staining. This study showed that Alendronate pellet which is crosslinked by glutaraldehyde has not been shown decreasing size defect. This effect might be due to has not been releases alendronate from the pellet or that is still very little apart, so there is no emphasis on resorption activity by osteoclast. Based on the measurement of bone cell count, it shown that alendronate pellet was crosslinked by glutaraldehid had better bone growth,proven effective in assisting the process of closing the bone defect due to fracture of osteoporosis significantly. 2018 Thesis NonPeerReviewed text id http://repository.unair.ac.id/76874/1/FF.FK.%2005-18%20Aul%20u%20Abstrak.pdf text id http://repository.unair.ac.id/76874/2/FF.FK.%2005-18%20Aul%20u.pdf FITROTIN AULIYAH, 051311133119 (2018) UJI EFEKTIVITAS PELET ALENDRONAT YANG DICROSSLINK DENGAN GLUTARALDEHID PADA CELAH TULANG AKIBAT FRAKTUR KARENA OSTEOPOROSIS. Skripsi thesis, Universitas Airlangga. http://lib.unair.ac.id |
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RD701-811 Orthopedic surgery RM300-666 Drugs and their actions |
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RD701-811 Orthopedic surgery RM300-666 Drugs and their actions FITROTIN AULIYAH, 051311133119 UJI EFEKTIVITAS PELET ALENDRONAT YANG DICROSSLINK DENGAN GLUTARALDEHID PADA CELAH TULANG AKIBAT FRAKTUR KARENA OSTEOPOROSIS |
description |
Osteoporosis is a bone disorder that is characterized
by decreasing the density and strength of bone, disruption of
bone architecture that may result in fracture. Osteoporosis
occurs when there is an increase in bone resorption process
that is far beyond the ability of osteoblast form new bone.
Esterogen deficiency is one of events that can cause
osteoporosis.
The objective of this research was to determine the
effectiveness of pellet alendronate which is crosslinked by
glutaraldehyde for the defect of fracture that caused by
osteoporosis. The rats were ovariectomized on the 8th day
after were adapted for 7 days, then drilling on the femur was
2.2 mm and then treated according to the group (Give pellet
or not). After that, terminate them to take the femur at 6th
week after drilling. Then, performed observation on the
defect either radiologically and Haematoxylin-Eosin staining.
This study showed that Alendronate pellet which is
crosslinked by glutaraldehyde has not been shown decreasing
size defect. This effect might be due to has not been releases
alendronate from the pellet or that is still very little apart, so
there is no emphasis on resorption activity by osteoclast.
Based on the measurement of bone cell count, it shown that
alendronate pellet was crosslinked by glutaraldehid had better
bone growth,proven effective in assisting the process of
closing the bone defect due to fracture of osteoporosis
significantly. |
format |
Theses and Dissertations NonPeerReviewed |
author |
FITROTIN AULIYAH, 051311133119 |
author_facet |
FITROTIN AULIYAH, 051311133119 |
author_sort |
FITROTIN AULIYAH, 051311133119 |
title |
UJI EFEKTIVITAS PELET ALENDRONAT YANG DICROSSLINK DENGAN GLUTARALDEHID PADA CELAH TULANG AKIBAT FRAKTUR KARENA OSTEOPOROSIS |
title_short |
UJI EFEKTIVITAS PELET ALENDRONAT YANG DICROSSLINK DENGAN GLUTARALDEHID PADA CELAH TULANG AKIBAT FRAKTUR KARENA OSTEOPOROSIS |
title_full |
UJI EFEKTIVITAS PELET ALENDRONAT YANG DICROSSLINK DENGAN GLUTARALDEHID PADA CELAH TULANG AKIBAT FRAKTUR KARENA OSTEOPOROSIS |
title_fullStr |
UJI EFEKTIVITAS PELET ALENDRONAT YANG DICROSSLINK DENGAN GLUTARALDEHID PADA CELAH TULANG AKIBAT FRAKTUR KARENA OSTEOPOROSIS |
title_full_unstemmed |
UJI EFEKTIVITAS PELET ALENDRONAT YANG DICROSSLINK DENGAN GLUTARALDEHID PADA CELAH TULANG AKIBAT FRAKTUR KARENA OSTEOPOROSIS |
title_sort |
uji efektivitas pelet alendronat yang dicrosslink dengan glutaraldehid pada celah tulang akibat fraktur karena osteoporosis |
publishDate |
2018 |
url |
http://repository.unair.ac.id/76874/1/FF.FK.%2005-18%20Aul%20u%20Abstrak.pdf http://repository.unair.ac.id/76874/2/FF.FK.%2005-18%20Aul%20u.pdf http://repository.unair.ac.id/76874/ http://lib.unair.ac.id |
_version_ |
1681150675964133376 |