POTENSI TERAPI EKSTRAK KULIT MANGGIS (Garcinia mangostana) TERHADAP KERUSAKAN MUKOSA KOLON PADA MODEL HEWAN COBA MENCIT INFEKSI Shigella dysenteriae

• Main Author: Achmad Ilham Rizwani, NIM011511133026
• Format: Theses and Dissertations NonPeerReviewed
• Language: Indonesian; Indonesian
• Published: 2018
• Subjects: RC31-1245 Internal medicine; RM Therapeutics. Pharmacology
• Online Access: http://repository.unair.ac.id/76952/1/ABSTRAK.pdf; http://repository.unair.ac.id/76952/2/FK.%20PD.%2087-18%20Riz%20p.pdf; http://repository.unair.ac.id/76952/; http://lib.unair.ac.id
• Institution: Universitas Airlangga

Background : Antibiotics treatment for bacillary dysentery due to Shigella dysenteriae infection have shown resistency. Mangosteen (Garcinia maangostana) rind have a therapy potency for Shigella dysenteriae infection due to its antibacterial, antiinflamation, and antioxidant activity. Objectives : Studying the potency of therapy with mangosteen (Garcinia mangostana) rind to mice’s colon mucose with Shigella dysenteriae infection. Methods : This research was an experimintal research, 30 mices was used which divided to 5 groups. The mices was infected with Shigella dysenteriae intraperitoneally, then azithromycin, aquadest, and 3 different doses of mangosteen (Garcinia mangostana) rind was given for each group for 5 days, which then the mice’s colon was collected and made into histopathology slide and its mucosal destruction was observed in 3 fields of view in each slide, 1 – 4 score was given acording to its mucosal destruction. Kruskal-Wallis test is used to analyzed the data and then Mann Whitney test also used for further analyze. Result : there was a healing effect obeserved when mangosteen (Garcinia mangostana) rind extract was given to the mice’s colon mucosal, 100 mg/Kg body mass dose of mangosteen (Garcinia mangostana) rind extract already given a positive effect on mice’s mucosal colon histopathological appearance, no difference observed between 3 dose given. Conclusion : Mangosteen (Garcinia mangostana) rind extract consumption gave healing appearance to destruction of colon mucosal wall of mices with Shigella dysenteriae infection at 100 mg/Kg body mass. Keyword : Mangosteen rind extract, Shigella dysenteriae, bacillary dysenteriae, Mice’s colon mucosal