PROFIL PENGGUNAAN OBAT ANTIHIPERTENSI PADA PASIEN ANAK DENGAN LUPUS NEFRITIS (Penelitian di IRNA Anak SMF Ilmu Kesehatan Anak RSUD Dr. Soetomo Surabaya)
Lupus nephritis (LN) is an autoimmune disease often occurred in recent years. One of the major causes of mortality and morbidity in patients with LN is cardiovascular disease, primarily hypertension. The purpose of hypertension treatment in children with LN is to reduce the short-term and long-t...
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| Main Author: | |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | Indonesian Indonesian |
| Published: |
2018
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| Subjects: | |
| Online Access: | http://repository.unair.ac.id/76994/1/FF.FK.%2044-18%20Rac%20p%20Abstrak.pdf http://repository.unair.ac.id/76994/2/FF.FK.%2044-18%20Rac%20p.pdf http://repository.unair.ac.id/76994/ http://lib.unair.ac.id |
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| Institution: | Universitas Airlangga |
| Language: | Indonesian Indonesian |
| Summary: | Lupus nephritis (LN) is an autoimmune disease often occurred in
recent years. One of the major causes of mortality and morbidity in patients
with LN is cardiovascular disease, primarily hypertension. The purpose of
hypertension treatment in children with LN is to reduce the short-term and
long-term risks of cardiovascular disease and organ damage. The
recommended antihypertensive agent is RAAS inhibiting therapy, because
it can lower the blood pressure and also has renoprotective and
antiproteinuria effects. In addition, other antihypertensive agents suggested
are diuretics and CCB due to its role in controlling hypertension in pediatric
patients with lupus nephritis.
The purpose of this study was to analyze the profile of
antihypertensive agent based on type, dose, route of administration,
frequency of drug use and to identify side effects associated with the
antihypertensive agent. This study was conducted retrospectively by
descriptive analysis from January to December 2017 with 35 patients
fullfiled the inclusion criteria. The study had been ethically approved by
The Ethical Committee of Dr. Soetomo Teaching Hospital Surabaya.
The results showed that the distribution and dosage of
antihypertensive agent used in pediatric patients were ACEIs (captopril
0,1-2 mg/kg/day and lisinopril 0,1-1 mg/kg/day); CCBs (amlodipine
0,05-0,2 mg/kg/day and nifedipine 0,25-1 mg/kg/dose); ARB (losartan
0,5-1,4 mg/kg/day), and diuretics (furosemide 0,5-1 mg/kg/times). The
selection of antihypertensive agents were based on patient's condition
related to clinical and laboratory data assessment. The drug utilization of
antihypertensive agents including type, dose, route of administration, and
frequency of drug use were in accordance with the guidelines of
Dr. Soetomo Teaching Hospital clinical practice. |
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