PENGARUH PEMBERIAN EKSTRAK DAUN YAKON (Smallanthus sonchifolius) TERHADAP GAMBARAN HISTOPATOLOGI TUBULUS SEMINIFERUS TIKUS PUTIH YANG DIINDUKSI ALOKSAN

• Main Author: CHORIK DWI AGUSTIN, 061411131115
• Format: Theses and Dissertations NonPeerReviewed
• Language: English; Indonesian
• Published: 2018
• Subjects: SF405.5-407 Laboratory animals
• Online Access: http://repository.unair.ac.id/77070/1/KKC%20KK%20KH.166-18%20Agu%20p%20ABSTRAK.pdf; http://repository.unair.ac.id/77070/2/KKC%20KK%20KH.166-18%20Agu%20p%20SKRIPSI.pdf; http://repository.unair.ac.id/77070/; http://lib.unair.ac.id
• Institution: Universitas Airlangga

The aim of this research was to know the effect of yacon’s leaves (S. sonchifolius) extract can reform the histological seminiferous tubule of white rat (Rattus norvegicus) exposed by alloxan induction. Alloxan were intraperitoneally injected 120 mg/kgBW as single dose. A total of twenty three-month-old male rats were used in study. The rats were divided into five groups, 1) negative control group (K-) without alloxan induction and given with CMC Na 0.5% 0,01 ml/gBW, 2) positive control group (K+) within alloxan induction and given with CMC Na 0.5% 0.01 ml/gBW, 3) within alloxan induction and extract of Smallanthus sonchifolius 200 mg/kgBW (P1), 4) within alloxan induction and extract of Smallanthus sonchifolius 400 mg/kgBW (P2), 5) within alloxan induction and extract of Smallanthus sonchifolius 800 mg/kgBW (P3). Rats were treated for 28 days. The data of this study was analyzed by Kruskal-wallis and followed with Mann-withney test. The result of this study is Smallanthus sonchifolius can reform the histological seminiferous tubule of white rat (Rattus norvegicus) exposed by alloxan induction. The increased dose of ethanol extract of yacon’s leaves was not effective to reform the histological seminiferous tubule of white rat (Rattus norvegicus) Wistar strain induced by alloxan.