PEMBERIAN EKSTRAK BUAH DELIMA (Punica granatum L.) TERSTANDARISASI 40% Ellagic acid TERHADAP GAMBARAN HISTOPATOLOGIS DIAMETER DAN TEBAL EPITEL TUBULUS SEMINIFERUS TIKUS PUTIH (Rattus norvegicus) YANG TERPAPAR PANAS

• Main Author: NURFITRI RAHMAH DANINGTIA, 061311133106
• Format: Theses and Dissertations NonPeerReviewed
• Language: English; Indonesian
• Published: 2018
• Subjects: SF405.5-407 Laboratory animals
• Online Access: http://repository.unair.ac.id/77104/1/KKC%20KK%20KH.173-18%20Dan%20p%20ABSTRAK.pdf; http://repository.unair.ac.id/77104/2/KKC%20KK%20KH.173-18%20Dan%20p%20SKRIPSI.pdf; http://repository.unair.ac.id/77104/; http://lib.unair.ac.id
• Institution: Universitas Airlangga

This study aimed to determine the effect of pomegranate extract (Punica granatum L.) Standardized to 40% ellagic acid against histopathological picture diameter and thickness of the seminiferous tubule epithelium white rat (Rattus norvegicus) wistar strain were exposed to heat. This study used 25 rats 7-8 months old as experimental animals were randomly divided into 5 treatment groups. Rat in the negative control group not treated, solvent control group were given CMC Na 0,5% and it exposed to heat, the treatment groups 1, 2, and 3 induced pomegranate extract standardized to 40% ellagic acid at a dose of 75mg/kgBB, 150mg/kgBB and 300mg/kgBB and exposed to heat. At the end of the study take the right testes, then the testes made preparations with Hematoxylin eosin staining. Based on statistical data analysis, it shows significant difference between the lowest and highest a dose of p<0,05, with the most significant different treatment group induced pomegranate extract standardized to 40% ellagic acid at a dose of 75mg/kgBB and exposed to heat and treatment group induced pomegranate extract standardized to 40% ellagic acid at a dose of 300mg/kgBB and exposed to heat. In conclusion, the optimal dose of pomegranate extract standardized to 40% ellagic acid in supporting increase of fertility is a dose of 300mg/kgBB.