ANALISIS KADAR SERUM P1NP TERHADAP REGENERASI TULANG PADA PASIEN EPILEPSI DENGAN TERAPI TUNGGAL VALPROAT ATAU FENITOIN JANGKA PANJANG (Penelitian dilakukan di Poli Saraf Instalasi Rawat Jalan RSU Haji Surabaya)

• Main Author: Ayu Mawari, 051615153035
• Format: Theses and Dissertations NonPeerReviewed
• Language: Indonesian; Indonesian
• Published: 2018
• Subjects: RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry; RM Therapeutics. Pharmacology
• Online Access: http://repository.unair.ac.id/77123/1/TFK.%2038-18%20Maw%20a%20Abstrak.pdf; http://repository.unair.ac.id/77123/2/TFK.%2038-18%20Maw%20a.pdf; http://repository.unair.ac.id/77123/; http://lib.unair.ac.id
• Institution: Universitas Airlangga

BACKGROUND – According to WHO 2018, epilepsy affects ~50 million people worldwide. Mortality rates of epilepsy in the developing countries are reported to be higher than under developed countries. Patients with epilepsy have a risk of fractures about 2-6 times greater than general population. Valproate and phenytoin reported to be associated with decreased bone mineral density (BMD), changes in bone turnover and increased risk of fractures. OBJECTIVE – The aim of this prospective study was to analyze serum P1NP levels as marker of bone formation in epilepsy patients who received long-term valproate or phenytoin therapy. METHOD – The serum P1NP levels were measured on routine patient visit to ambulatory care of neurology department. Sample was collected by consecutive sampling in cross sectional study from August – September 2018. Protocol of this study had been reviewed by Ethical Committee Haji General Hospital Surabaya. P1NP were measured with ELISA and statistical analysis was analyzed by Independent T Test and Pearson correlation. RESULT – A total of 22 patients participated in this study. The serum P1NP levels were obtained in the valproate group (mean 182.63 ± 18.24ng/ml) lower than phenytoin group (mean 451 ± 105,1ng/ml) in long term use with normal reference in healthy subject (20- 480ng/ml). No correlation was found between serum P1NP levels with age, gender, height, body mass index (BMI), and duration of AED. CONCLUSION – Patients with a history of prolonged use of valproate or phenytoin suggested for BMD testing and recommended for supplementation of calcium and vitamin D due to risk of fractures.