PENGARUH JUMLAH KITOSAN TERHADAP LAJU PELEPASAN ANDROGRAFOLID DARI MIKROPARTIKEL ANDROGRAFOLID-KITOSAN (Dibuat dengan metode gelasi ionik-pengeringan beku)
Andrographolide has low solubility and short half life (t1/2 = 1,5-2 hours). Therefore andrographolide has a low bioavailability. Andrographolide-chitosan microparticles was expected to improve dissolution and further could increase bioavailability of andrographolide. The objective of this research...
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id-langga.772142018-12-27T05:39:31Z http://repository.unair.ac.id/77214/ PENGARUH JUMLAH KITOSAN TERHADAP LAJU PELEPASAN ANDROGRAFOLID DARI MIKROPARTIKEL ANDROGRAFOLID-KITOSAN (Dibuat dengan metode gelasi ionik-pengeringan beku) WAFIQOH AMIRAH, 051411131053 RS1-441 Pharmacy and materia medica Andrographolide has low solubility and short half life (t1/2 = 1,5-2 hours). Therefore andrographolide has a low bioavailability. Andrographolide-chitosan microparticles was expected to improve dissolution and further could increase bioavailability of andrographolide. The objective of this research was to investigate the effect of chitosan concentration on infrared spectrum and in vitro release of andrographolide from microparticles. Microparticles were prepared by ionic gelation and used sodium tripolyphosphate (TPP) as cross linker and dried by freeze drying method. The chitosan concentration that used in this research were 0,5% (L0,5), 0,625% (L0,75) and 0,75% (L0,75). Infrared spectrum of microparticles shows that there was ionic bonding between chitosan and TPP. The model of release kinetics suitable for andrographolide-chitosan microparticles system was The Higuchi model. Release rate of microparticles in phosphate buffer pH 7 ± 0,05 are higher than andrographolide as control. It show that andrographolide-chitosan microparticles are able to enhance dissolution rate of andrographolide. 2018 Thesis NonPeerReviewed text id http://repository.unair.ac.id/77214/1/FF.F.%2017-18%20Ami%20p%20Abstrak.pdf text id http://repository.unair.ac.id/77214/2/FF.F.%2017-18%20Ami%20p.pdf WAFIQOH AMIRAH, 051411131053 (2018) PENGARUH JUMLAH KITOSAN TERHADAP LAJU PELEPASAN ANDROGRAFOLID DARI MIKROPARTIKEL ANDROGRAFOLID-KITOSAN (Dibuat dengan metode gelasi ionik-pengeringan beku). Skripsi thesis, Universitas Airlangga. http://lib.unair.ac.id |
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RS1-441 Pharmacy and materia medica WAFIQOH AMIRAH, 051411131053 PENGARUH JUMLAH KITOSAN TERHADAP LAJU PELEPASAN ANDROGRAFOLID DARI MIKROPARTIKEL ANDROGRAFOLID-KITOSAN (Dibuat dengan metode gelasi ionik-pengeringan beku) |
description |
Andrographolide has low solubility and short half life (t1/2 = 1,5-2 hours). Therefore andrographolide has a low bioavailability. Andrographolide-chitosan microparticles was expected to improve dissolution and further could increase bioavailability of andrographolide. The objective of this research was to investigate the effect of chitosan concentration on infrared spectrum and in vitro release of andrographolide from microparticles. Microparticles were prepared by ionic gelation and used sodium tripolyphosphate (TPP) as cross linker and dried by freeze drying method. The chitosan concentration that used in this research were 0,5% (L0,5), 0,625% (L0,75) and 0,75% (L0,75). Infrared spectrum of microparticles shows that there was ionic bonding between chitosan and TPP.
The model of release kinetics suitable for andrographolide-chitosan microparticles system was The Higuchi model. Release rate of microparticles in phosphate buffer pH 7 ± 0,05 are higher than andrographolide as control. It show that andrographolide-chitosan microparticles are able to enhance dissolution rate of andrographolide. |
format |
Theses and Dissertations NonPeerReviewed |
author |
WAFIQOH AMIRAH, 051411131053 |
author_facet |
WAFIQOH AMIRAH, 051411131053 |
author_sort |
WAFIQOH AMIRAH, 051411131053 |
title |
PENGARUH JUMLAH KITOSAN TERHADAP LAJU PELEPASAN ANDROGRAFOLID DARI MIKROPARTIKEL ANDROGRAFOLID-KITOSAN (Dibuat dengan metode gelasi ionik-pengeringan beku) |
title_short |
PENGARUH JUMLAH KITOSAN TERHADAP LAJU PELEPASAN ANDROGRAFOLID DARI MIKROPARTIKEL ANDROGRAFOLID-KITOSAN (Dibuat dengan metode gelasi ionik-pengeringan beku) |
title_full |
PENGARUH JUMLAH KITOSAN TERHADAP LAJU PELEPASAN ANDROGRAFOLID DARI MIKROPARTIKEL ANDROGRAFOLID-KITOSAN (Dibuat dengan metode gelasi ionik-pengeringan beku) |
title_fullStr |
PENGARUH JUMLAH KITOSAN TERHADAP LAJU PELEPASAN ANDROGRAFOLID DARI MIKROPARTIKEL ANDROGRAFOLID-KITOSAN (Dibuat dengan metode gelasi ionik-pengeringan beku) |
title_full_unstemmed |
PENGARUH JUMLAH KITOSAN TERHADAP LAJU PELEPASAN ANDROGRAFOLID DARI MIKROPARTIKEL ANDROGRAFOLID-KITOSAN (Dibuat dengan metode gelasi ionik-pengeringan beku) |
title_sort |
pengaruh jumlah kitosan terhadap laju pelepasan andrografolid dari mikropartikel andrografolid-kitosan (dibuat dengan metode gelasi ionik-pengeringan beku) |
publishDate |
2018 |
url |
http://repository.unair.ac.id/77214/1/FF.F.%2017-18%20Ami%20p%20Abstrak.pdf http://repository.unair.ac.id/77214/2/FF.F.%2017-18%20Ami%20p.pdf http://repository.unair.ac.id/77214/ http://lib.unair.ac.id |
_version_ |
1681150734701166592 |