PENGARUH JUMLAH KARBOKSIMETIL KITOSAN TERHADAP KARAKTERISTIK FISIK DAN LAJU DISOLUSI SISTEM DISPERSI PADAT ANDROGRAFOLID-KARBOKSIMETIL KITOSAN (Metode Pelarutan dan Pengeringan Semprot)
Andrographolide is a diterpene lactone present in Andrographis paniculata, has a wide pharmacological activities, including analgesic, antipyretic, anti-inflammatory, hepatoprotective effect, antiviral, and anti thrombotic. Andrographolide has a low aqueous solubility and low bioavailability aft...
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| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | Indonesian Indonesian |
| Published: |
2018
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| Subjects: | |
| Online Access: | http://repository.unair.ac.id/77224/1/FF.F.%2024-18%20Naf%20p%20Abstrak.pdf http://repository.unair.ac.id/77224/2/FF.F.%2024-18%20Naf%20p.pdf http://repository.unair.ac.id/77224/ http://lib.unair.ac.id |
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| Institution: | Universitas Airlangga |
| Language: | Indonesian Indonesian |
| Summary: | Andrographolide is a diterpene lactone present in Andrographis
paniculata, has a wide pharmacological activities, including analgesic,
antipyretic, anti-inflammatory, hepatoprotective effect, antiviral, and anti
thrombotic. Andrographolide has a low aqueous solubility and low
bioavailability after oral administration. Solid dispersions of
andrographolide using carboxymethyl chitosan carriers increased solubility
and dissolution rate of andrographolide. Andrographolide-carboxymetyl
chitosan solid dispersions prepared by solubilitation and spray drying
method. The objective of this research was studying the effects of
carboxymethyl chitosan concentration on physical characteristics and
dissolution rate of andrographolide-carboxymethyl chitosan solid
dispersions. Characterization of solid dispersions was done using Scanning
Electron Microscopy (SEM), Differential Thermal Analysis (DTA),
Fourrier Transform Infrared Spectrometer (FTIR), and X-Ray Diffracton.
The SEM result showed that increased carboximethyl chitosan
concentration will decrease the number of andrographolide crystal. DTA
thermogram of solid dispersions showed a decreased in the melting point
temperature and X-Ray Diffraction showed decreased crystallinity of
andrographolide. Solid dispersions of andrographolide-carboxymethyl
chitosan with ratio 1:5 (F5) has found to have the highest solubility,
dissolution efficiency and dissolution rate. |
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