AKTIVITAS PROFILAKSIS ANTIMALARIA EKSTRAK ETANOL DAUN Sauropus androgynus (L.) Merr. SECARA IN VIVO TERHADAP MENCIT TERINFEKSI Plasmodium berghei

• Main Author: HAWI QUEEN NISA, 051411131028
• Format: Theses and Dissertations NonPeerReviewed
• Language: Indonesian; Indonesian
• Published: 2018
• Subjects: RS1-441 Pharmacy and materia medica
• Online Access: http://repository.unair.ac.id/77400/1/FF.FT.%2020-18%20%E2%81%AENis%20a%20Abstrak.pdf; http://repository.unair.ac.id/77400/2/FF.FT.%2020-18%20%E2%81%AENis%20a.pdf; http://repository.unair.ac.id/77400/; http://lib.unair.ac.id
• Institution: Universitas Airlangga

Malaria is an infectious disease transmitted through the bite of Anopheles mosquito infected by parasites named Plasmodium sp. In the face of current resistence problems, medicinal plant are a potential source of new, effective and affordable antimalarial agents, one of the plants is Sauropus androgynus. This study aimed to investigate in vivo antimalarial prophylaxis activity of S. androgynus (L) Merr leaves extract in inhibiting the growth of parasitemia. The extract was administered using a dosage of 100; 200; 400 mg / kgBW for the pre-infectious group and 100; 200 mg / kgBW for the continued administration after infection. The extract would be administered for four consecutive days (D0 to D3), on the four day (D3) after 2 hours administered extracy, a standard inoculum (2 x 106P. berghei, 0,2 ml) was administered by IP to each mouse. Blood was taken from mice tail and observed the percentage of parasitemia on day 3 -7. Based on the results of various percentages inhibition of ethanol extract of S. androgynus leaves on growth of P. berghei, it was obtained that ethanol extract of S. androgynus leaves has antimalarial prophylaxis activity at 400 mg/ kgBW and had ED50 value 158,29 mg/kgBW againts P. berghei, continued dose had more effective than the test group.