GAMBARAN MIKROSKOPIS TESTIS DAN KUALITAS SPERMA TIKUS PADA UJI TOKSISITAS SUBKRONIK EKSTRAK ETANOL 70% TERFRAKSINASI DAUN Justicia gendarussa Burm. f.
The ethanolic extract of Justicia gendarussa Burm. f. have been used by Irian Jaya’s people as man contraception drugs. The preclinical trial showed that 60% ethanolic extract of Justicia gendarussa Burm. f. effective inhibits mice fertilization and have no danger toxcicity. Clinical trial phase 1 e...
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| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | Indonesian Indonesian |
| Published: |
2018
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| Subjects: | |
| Online Access: | http://repository.unair.ac.id/77405/1/FF.FT.%2027-18%20%E2%81%AEKur%20g%20Abstrak.pdf http://repository.unair.ac.id/77405/2/FF.FT.%2027-18%20%E2%81%AEKur%20g.pdf http://repository.unair.ac.id/77405/ http://lib.unair.ac.id |
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| Institution: | Universitas Airlangga |
| Language: | Indonesian Indonesian |
| Summary: | The ethanolic extract of Justicia gendarussa Burm. f. have been used by Irian Jaya’s people as man contraception drugs. The preclinical trial showed that 60% ethanolic extract of Justicia gendarussa Burm. f. effective inhibits mice fertilization and have no danger toxcicity. Clinical trial phase 1 evaluated safety of 70 % ethanolic extract of Justicia gendarussa Burm. f, there is no effect on subject healthy. Clinical trial phase 2 evaluated efficay of 70 % ethanolic extract of Justicia gendarussa Burm.f, showed that 70 % ethanolic extract of Justicia gendarussa Burm is effective inhibits fertilization. This subchronic toxcicity study evaluted is there any effect of fractionated 70 % ethanolic extract of Justicia gendarussa Burm. f in histological testes and sperm quality.
A total of 40 wistar rats divided in 4 groups. The control group was given CMC-Na 0,5 %. The group I was given 40 mg/Kg BW 70 % ethanolic extract of Justicia gendarussa Burm.f. The group II was given 200 mg/Kg BW 70 % ethanolic extract of Justicia gendarussa Burm.f. The group III was given 1000 mg/Kg BW 70 % ethanolic extract of Justicia gendarussa Burm.f. After 90 days all rats was killed sperm from cauda epididimis was collected and testes was evaluated. In this study showed that fractionated 70 % ethanolic extract of Justicia gendarussa Burm.f can decrease motility, viablity and concentration spermatozoa. Fractionated 70 % ethanolic extract of Justicia gendarussa Burm.f can decrease seminifereous tubule diameter’s, increase seminifereous tubule thickness and decrease total spermatogenic cell, but no effect on Leydig cell. |
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