Design, synthesis and Central Nervous System depressant activity test of the new compound N’-phenyl-N-benzoylurea

• Main Author: Purwanto, Bambang Tri
• Format: Article PeerReviewed
• Language: English; English
• Published: School of Pharmacy, People's Unviersity 2014
• Subjects: R Medicine; RS Pharmacy and materia medica; RS1-441 Pharmacy and materia medica; RS200-201 Pharmaceutical dosage forms
• Online Access: http://repository.unair.ac.id/77454/2/C-3.pdf; http://repository.unair.ac.id/77454/3/Validasi%20dan%20Reviewer%20C-3.pdf; http://repository.unair.ac.id/77454/; http://www.wjpr.net/dashboard/abstract_id/897
• Institution: Universitas Airlangga

Design and synthesis the new compound N’phenyl-N-benzoylurea has been done. N’phenyl-N-benzoylurea was designed by In Silico by Molegro Virtual Docker Program to predict its activity as the central nervous system depressant . The Schotten Baumann method was used for the reaction between N-phenylurea and benzoyl chloride to produced N’-phenyl-N-benzoylurea. The CNS depressant activity test was done for the N’phenyl-N-benzoylurea compound and compared with bromisoval as the standard reference by Barbituric Sleeping Time (BST) method. The compound N’-phenyl-N-benzoylurea bound as well as the standard reference bromisoval with the protein Pro 85, In Silico method. The compound yield was 86% , had a white crystal and gave one spot in Thin Layer Chromatography with two different eluent. The compound melting point was different from the N-phenylurea and showed greater. The structure identification from the new compound was analysed by UV, IR, 1-HNMR and MS, the result showed that the new compound was N’phenyl-N-benzoylurea. The CNS depressant activity test from N’phenyl-N-benzoylurea had a greater activity if compare with the reference compound bromisoval.