Design, synthesis and Central Nervous System depressant activity test of the new compound N’-phenyl-N-benzoylurea

Design and synthesis the new compound N’phenyl-N-benzoylurea has been done. N’phenyl-N-benzoylurea was designed by In Silico by Molegro Virtual Docker Program to predict its activity as the central nervous system depressant . The Schotten Baumann method was used for the reaction between N-phenyl...

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Main Author: Purwanto, Bambang Tri
Format: Article PeerReviewed
Language:English
English
Published: School of Pharmacy, People's Unviersity 2014
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Online Access:http://repository.unair.ac.id/77454/2/C-3.pdf
http://repository.unair.ac.id/77454/3/Validasi%20dan%20Reviewer%20C-3.pdf
http://repository.unair.ac.id/77454/
http://www.wjpr.net/dashboard/abstract_id/897
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Institution: Universitas Airlangga
Language: English
English
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spelling id-langga.774542019-01-09T02:04:30Z http://repository.unair.ac.id/77454/ Design, synthesis and Central Nervous System depressant activity test of the new compound N’-phenyl-N-benzoylurea Purwanto, Bambang Tri R Medicine RS Pharmacy and materia medica RS1-441 Pharmacy and materia medica RS200-201 Pharmaceutical dosage forms Design and synthesis the new compound N’phenyl-N-benzoylurea has been done. N’phenyl-N-benzoylurea was designed by In Silico by Molegro Virtual Docker Program to predict its activity as the central nervous system depressant . The Schotten Baumann method was used for the reaction between N-phenylurea and benzoyl chloride to produced N’-phenyl-N-benzoylurea. The CNS depressant activity test was done for the N’phenyl-N-benzoylurea compound and compared with bromisoval as the standard reference by Barbituric Sleeping Time (BST) method. The compound N’-phenyl-N-benzoylurea bound as well as the standard reference bromisoval with the protein Pro 85, In Silico method. The compound yield was 86% , had a white crystal and gave one spot in Thin Layer Chromatography with two different eluent. The compound melting point was different from the N-phenylurea and showed greater. The structure identification from the new compound was analysed by UV, IR, 1-HNMR and MS, the result showed that the new compound was N’phenyl-N-benzoylurea. The CNS depressant activity test from N’phenyl-N-benzoylurea had a greater activity if compare with the reference compound bromisoval. School of Pharmacy, People's Unviersity 2014-05 Article PeerReviewed text en http://repository.unair.ac.id/77454/2/C-3.pdf text en http://repository.unair.ac.id/77454/3/Validasi%20dan%20Reviewer%20C-3.pdf Purwanto, Bambang Tri (2014) Design, synthesis and Central Nervous System depressant activity test of the new compound N’-phenyl-N-benzoylurea. World Journal of Pharmaceutical Research, 3 (3). pp. 4797-4808. ISSN 2277-7105 http://www.wjpr.net/dashboard/abstract_id/897
institution Universitas Airlangga
building Universitas Airlangga Library
country Indonesia
collection UNAIR Repository
language English
English
topic R Medicine
RS Pharmacy and materia medica
RS1-441 Pharmacy and materia medica
RS200-201 Pharmaceutical dosage forms
spellingShingle R Medicine
RS Pharmacy and materia medica
RS1-441 Pharmacy and materia medica
RS200-201 Pharmaceutical dosage forms
Purwanto, Bambang Tri
Design, synthesis and Central Nervous System depressant activity test of the new compound N’-phenyl-N-benzoylurea
description Design and synthesis the new compound N’phenyl-N-benzoylurea has been done. N’phenyl-N-benzoylurea was designed by In Silico by Molegro Virtual Docker Program to predict its activity as the central nervous system depressant . The Schotten Baumann method was used for the reaction between N-phenylurea and benzoyl chloride to produced N’-phenyl-N-benzoylurea. The CNS depressant activity test was done for the N’phenyl-N-benzoylurea compound and compared with bromisoval as the standard reference by Barbituric Sleeping Time (BST) method. The compound N’-phenyl-N-benzoylurea bound as well as the standard reference bromisoval with the protein Pro 85, In Silico method. The compound yield was 86% , had a white crystal and gave one spot in Thin Layer Chromatography with two different eluent. The compound melting point was different from the N-phenylurea and showed greater. The structure identification from the new compound was analysed by UV, IR, 1-HNMR and MS, the result showed that the new compound was N’phenyl-N-benzoylurea. The CNS depressant activity test from N’phenyl-N-benzoylurea had a greater activity if compare with the reference compound bromisoval.
format Article
PeerReviewed
author Purwanto, Bambang Tri
author_facet Purwanto, Bambang Tri
author_sort Purwanto, Bambang Tri
title Design, synthesis and Central Nervous System depressant activity test of the new compound N’-phenyl-N-benzoylurea
title_short Design, synthesis and Central Nervous System depressant activity test of the new compound N’-phenyl-N-benzoylurea
title_full Design, synthesis and Central Nervous System depressant activity test of the new compound N’-phenyl-N-benzoylurea
title_fullStr Design, synthesis and Central Nervous System depressant activity test of the new compound N’-phenyl-N-benzoylurea
title_full_unstemmed Design, synthesis and Central Nervous System depressant activity test of the new compound N’-phenyl-N-benzoylurea
title_sort design, synthesis and central nervous system depressant activity test of the new compound n’-phenyl-n-benzoylurea
publisher School of Pharmacy, People's Unviersity
publishDate 2014
url http://repository.unair.ac.id/77454/2/C-3.pdf
http://repository.unair.ac.id/77454/3/Validasi%20dan%20Reviewer%20C-3.pdf
http://repository.unair.ac.id/77454/
http://www.wjpr.net/dashboard/abstract_id/897
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