Synthesis, molecular docking and anti tumor activity of N,N-Carbonylbis (N-ethylbenzamide)
We have designed and synthesized N,N’-carbonylbis(N-ethylbenzamide) to find new urea derivative with antitumor activity. The compound was synthesized from reaction of N,N’-diethylurea and benzoyl chloride in tetrahydrofuran. The designed molecule was docked into binding site of p38 MAP Kinase (pd...
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| Main Authors: | , , |
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| Format: | Article PeerReviewed |
| Language: | English English |
| Published: |
Atom and Cell Publisher
2015
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| Subjects: | |
| Online Access: | http://repository.unair.ac.id/77464/1/C-8.pdf http://repository.unair.ac.id/77464/2/Validasi%20dan%20Reviewer%20C-8.pdf http://repository.unair.ac.id/77464/ http://www.wjpsonline.org/admin/uploads/yaPWDK.pdf |
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| Institution: | Universitas Airlangga |
| Language: | English English |
| Summary: | We have designed and synthesized N,N’-carbonylbis(N-ethylbenzamide) to find new urea derivative with
antitumor activity. The compound was synthesized from reaction of N,N’-diethylurea and benzoyl chloride in
tetrahydrofuran. The designed molecule was docked into binding site of p38 MAP Kinase (pdb. 3HEG) to
predict its binding affinity. The antitumor activity was tested in vitro on human breast cancer cell line (MCF-7
and T47D) by MTT assay and compared with hydroxyurea as a reference compound. The synthesis yield 30%
and confirmed as N,N’-carbonylbis(N-ethylbenzamide) by spectroscpopic data. The compound showed higher in
vitro antitumor activity than hydroxyurea either against MCF-7 or T47D and displayed better in silico binding
property. It concluded that the synthesized compound is recommended to be developed further antitumor agents
for human breast cancer. |
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