PENGARUH KADAR HPMC 606 TERHADAP KARAKTERISTIK DAN EFEK ANTIINFLAMASI SEDIAAN MELOKSIKAM DALAM SISTEM NANOSTRUCTURED LIPID CARRIER (NLC) PADA PATCH TIPE MEMBRAN
Transdermal drug delivery is a controlled release of drugs through the skin to obtain therapeutic effect locally or systemically. One of the dosage form of transdermal preparation is patch. Meloxicam, which formulated as transdermal patch, have a lot of potential advantages to avoid first pass me...
Saved in:
Main Author: | |
---|---|
Format: | Theses and Dissertations NonPeerReviewed |
Language: | English English |
Published: |
2019
|
Subjects: | |
Online Access: | http://repository.unair.ac.id/80971/1/abstrak.pdf http://repository.unair.ac.id/80971/2/full%20text.pdf http://repository.unair.ac.id/80971/ http://lib.unair.ac.id |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Universitas Airlangga |
Language: | English English |
Summary: | Transdermal drug delivery is a controlled release of drugs through the skin
to obtain therapeutic effect locally or systemically. One of the dosage form of
transdermal preparation is patch. Meloxicam, which formulated as transdermal patch,
have a lot of potential advantages to avoid first pass metabolism, maintain constant
therapeutic levels as local site, minimize side effect and avoid gastrointestinal adverse
effect due to local contact with mucosa by oral administration so is can improve
compliance. This research has been investigated the effect of concentration of HPMC
606 5%, 10%, 15%, and 20% on the characteristics and inflammatory effect of
meloxicam transdermal patch. Meloxicam NLC system with lipid ratio 80 : 20
(monostearin and alpha tocopheryl acetate) were used as drug reservoir and
hydroxypropil methylcellulose 606 (HPMC 606) as rate controlling membrane. NLC
meloxicam as drug reservoir were prepared using high shear homogenization method.
The transdermal patch were evaluated for thickness, weight variation, moisture
content, uniformity content and homogeneity. All independent variables had
significant effect on the dependent variables (p-values < 0.05) using one way
ANOVA, except the weight uniformity content and homogeneity. The rat paw edema
test was performed to evaluate the anti-inflamatory activity of patch meloxicam, F1
with lowest levels of HPMC 606 (5%) had provide most effective anti-inflammatory
effect. |
---|