Pengaruh Fitosom dan Kompleks Inklusi siklodekstrin ekstrak etanol 70% Daun ungu (Graptophyllum pictum Griff.) pada struktur morfologi sel darah merah secara in vitro dan in vivo
The present study was an attempt to investigate toxic effects of phytosome and inclusion complex on red blood cell (RBC) under in vitro and in vivo test, by way of the red blood cell morphology (RBC) in vitro and in vivo test. On in vitro test, A number of 20 μl of each sample was added to 180 μl...
Saved in:
Main Author: | |
---|---|
Format: | Theses and Dissertations NonPeerReviewed |
Language: | English English |
Published: |
2019
|
Subjects: | |
Online Access: | http://repository.unair.ac.id/80976/1/abstrak.pdf http://repository.unair.ac.id/80976/2/full%20text.pdf http://repository.unair.ac.id/80976/ http://lib.unair.ac.id |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Universitas Airlangga |
Language: | English English |
Summary: | The present study was an attempt to investigate toxic effects of phytosome
and inclusion complex on red blood cell (RBC) under in vitro and in vivo test, by
way of the red blood cell morphology (RBC) in vitro and in vivo test. On in vitro
test, A number of 20 μl of each sample was added to 180 μl whole blood on 96-
well microplate V-bottom then observed after 45 minutes incubation. On in vivo
test, samples were induced in mice with a human dose of 20 mg flavonoid total and
were converted to mice doses. induction was administered for fourteen days, on the
fifteenth day the mice blood was observed under the microscope.
The crude extract, phytosome and inclusion complex of Grapthophyllum
pictum .L based on in vivo test there was no change of RBCs morphology, and
cause dose-dependent changes of RBCs morphology on in vitro test. This effect
may represent an early sign of toxicity. |
---|