VALIDASI METODE PENETAPAN KADAR SODIUM LAURIL SULFAT DALAM SEDIAAN TABLET SECARA SPEKTROFOTOMETRI UV-VIS

• Main Author: SALMAN SALIM, 051311133144
• Format: Theses and Dissertations NonPeerReviewed
• Language: English; English
• Published: 2019
• Subjects: RS1-441 Pharmacy and materia medica
• Online Access: http://repository.unair.ac.id/81982/1/abstrak.pdf; http://repository.unair.ac.id/81982/2/full%20text.pdf; http://repository.unair.ac.id/81982/; http://lib.unair.ac.id
• Institution: Universitas Airlangga

Simple, accurate and precise UV-Vis spectrophotometric method was validated for the determination of sodium lauryl sulfate (SLS) in tablet. The method based on the formation of chloroform extractable colored compound. The colored compound is the result of ion pairing complex between SLS with 0.005% methylene blue in phosphate buffer of pH 7.2. Showing the maximum absorption of the complex substance at 652 nm. The proposed method showed good linearity (r2 = 0.9969) in the range concentration of 2 ppm to 10 ppm. The precision was less than 5%, while accuracy of SLS was (98.59 ± 1,26) %. The proposed method is robust in pH variation of 0.2.