PENGARUH EMULSI LEMAK INTRAVENA DIPERKAYA MINYAK IKAN TERHADAP RESPONS INFLAMASI PADA ANAK PASCA PEMBEDAHAN GASTROINTESTINAL
Background: Surgery can increase morbidity and mortality due to the production of proinflammatory cytokines such as Interleukin (IL) -6, and tumor necrosis factor (TNF)-α. Intravenous fish oil-enriched lipid emulsion (FOLE) contains ω-3 which can reduce the release of proinflammatory cytokines. I...
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| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | Indonesian Indonesian |
| Published: |
2019
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| Subjects: | |
| Online Access: | http://repository.unair.ac.id/83341/1/PPDS.IKA.%2008-19%20Han%20p%20Abstrak.pdf http://repository.unair.ac.id/83341/2/PPDS.IKA.%2008-19%20Han%20p.pdf http://repository.unair.ac.id/83341/ http://lib.unair.ac.id |
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| Institution: | Universitas Airlangga |
| Language: | Indonesian Indonesian |
| Summary: | Background: Surgery can increase morbidity and mortality due to the production
of proinflammatory cytokines such as Interleukin (IL) -6, and tumor necrosis
factor (TNF)-α. Intravenous fish oil-enriched lipid emulsion (FOLE) contains ω-3
which can reduce the release of proinflammatory cytokines. Influence of FOLE on
modulation of inflammatory response compared to the standard Medium Chain
Trygliceride (MCT)/Long Chain Tryglyceride (LCT) emulsion in children postgastrointestinal
surgery has never been done.
Objective: To explain the influence of FOLE on modulation of inflammatory
response in children post-gastrointestinal surgery.
Method: A randomized controlled trial was conducted in August 2018 - January
2019 at Dr. Soetomo Hospital in children post-gastrointestinal surgery due to
esophageal and intestinal atresia that requires parenteral nutrition at least for 3
days. Samples were divided randomly into MCT/LCT and FOLE groups.
Laboratory and cytokines parameters are examined before and 3 days after
surgery.
Results: Of all, 7/14 were male and 7/14 got FOLE. There were no significant
differences in Hb, leukocyte, CRP, albumin, SGOT and SGPT levels in both
groups. Triglyceride levels were higher in the MCT/LCT group than FOLE (P =
0.041) on day 3. The difference in IL-6 levels was significant between the two groups before (p = 0.048), 3 days after surgery (p = 0.013) and differences in 3
days (p = 0.007). TNF-α levels were not significantly different compared to
MCT/LCT at day-3 post surgery (p = 0.796).
Conclusion: FOLE can decrease IL-6 and reduce triglyceride levels compared to
standard emulsions in postoperative children. |
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