EFEK PEMBERIAN TERAPI ADJUVAN DEKSAMETASON SUBKONJUNGTIVA TERHADAP KADAR TUMOR NECROSIS FACTOR ALPHA (TNF-α) DAN VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) DI CAIRAN VITREUS PADA PROLIFERATIVE VITREORETINOPATHY GRADE B-C (Studi Eksperimental pada Pasien Rhegmatogenous Retinal Detachment di RSUD Dr. Soetomo)
Introduction and Objective: To determine the effect of subconjunctival dexamethasone as adjuvant therapy in proliferative vitreoretinopathy (PVR) by measuring TNF-α and VEGF level in vitreous Method: Experimental study, 36 patients with PVR grade B-C were randomly divided into two groups, 20 pat...
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| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | Indonesian Indonesian |
| Published: |
2019
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| Subjects: | |
| Online Access: | http://repository.unair.ac.id/83465/1/PPDS.IKM.%2004-19%20Luk%20e%20Abstrak.pdf http://repository.unair.ac.id/83465/2/PPDS.IKM.%2004-19%20Luk%20e.pdf http://repository.unair.ac.id/83465/ http://lib.unair.ac.id |
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| Institution: | Universitas Airlangga |
| Language: | Indonesian Indonesian |
| Summary: | Introduction and Objective: To determine the effect of subconjunctival
dexamethasone as adjuvant therapy in proliferative vitreoretinopathy (PVR) by
measuring TNF-α and VEGF level in vitreous
Method: Experimental study, 36 patients with PVR grade B-C were randomly
divided into two groups, 20 patients in treatment group and 16 patients in control
group. Vitreous samples were collected undiluted at the beginning of pars plana
vitrectomy. All vitreous samples were immediately frozen at -80º C until assayed.
TNF-α and VEGF levels were measured using sandwich ELISA. The collected
data was processed using Independent t-test and Mann-Whitney test.
Result: The mean TNF-α level in treatment group was 0.71 ± 0.33 pg/ml and in
control group was 0.75 ± 0.25 pg/ml. There was no difference in intravitreal TNF-
α levels between two groups, p value = 0.697 (p> 0.05). The mean VEGF levels in
treatment group was 162.96 ± 302.75 pg/ml and control group was of 33.97 ±
48.57 pg/ml. There was no difference in intravitreal VEGF levels between the two
groups, p = 0.566 (p> 0.05).
Conclusion: Subconjunctival dexamethasone as a adjuvant therapy does not
provide a significant difference of TNF-α and VEGF level in PVR. It might be
caused by difference in grade of PVR and RD duration between two group, and
dexamethasone doesn’t reach expected effective dose for reducing the levels of
cytokine and growth factor in vitreous. |
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