Immunomodulation Effect of Meniran (Phyllanthus Niruri Linn) on blood profile of Broiler Chickens with enterotoxin of antibiotic resistant Escherichia coli

• Main Authors: Wahjuni, Retno Sri, Sabdoningrum, Emy Koestanti, Hidanah, Sri
• Format: Article PeerReviewed
• Language: English; English; English
• Published: Atlantis Press 2017
• Subjects: SF481-507 Poultry. Eggs; SF811-909 Veterinary medicine of special organs, regions, and systems
• Online Access: http://repository.unair.ac.id/83569/1/Bukti%20C32%20Immunomodulation%20Effect%20of%20Meniran%20...-compressed.pdf; http://repository.unair.ac.id/83569/2/Peer%20Review%20Bukti%2032%20oke.pdf; http://repository.unair.ac.id/83569/3/Bukti%2032%20Immunomodulation%20Effect%20of%20Meniran%20%28Phyllanthus%20niruri%20linn%29%20on%20Blood%20Profile%20of%20Broiler%20Chickens%20Infected%20with%20Enterotoxin%20of%20Antibiotic-Resistant%20Escherichia%20coli.pdf; http://repository.unair.ac.id/83569/; https://www.atlantis-press.com/proceedings/icpsuas-17/25891304
• Institution: Universitas Airlangga

The use of antibiotics against Escherichia coli on broiler chicken should be re-evaluated because antibioticresistant Escherichia coli has been found. Meniran ( Phyllanthus niruri Linn ) is a plant that can be used as an alternative to the prevention and treatment of the diseases caused by Escherichia coli enterotoxin. In this study, 28-day old broiler chickens were divided into six groups. Group 1 was a positive control group infected by Escherichia coli while group 2 was a negative control group without infection. The next group (group 3) were infected with Escherichia coli and given an extract of meniran of several different doses including 20%, 25%, and 30%, respectively. The last group used only an antibiotic as a treatment. Blood collection was conducted five days after treatment. The data obtained was analysed using ANOVA and was continued by a Duncan Multiple Range Test. The results showed that there was a significant difference in the immunomodulation activity in the group with 30% doses of meniran extract. The 30% doses of meniran extract were able to decrease the number of lymphocytes in the blood. In conclusion, a 30% concentration of meniran extract (Phyllanthus niruri L.) can decrease the number of lymphocytes in the blood of broiler chicken infected with the enterotoxin of antibioticsresistant Escherichia coli. Keywords: Immunomodulation, Phyllanthus niruri Linn.extract, Broiler, Escherichia coli