Penurunan Estrus dan Gambaran Histopatologis Ovarium Mencit (Mus musculus) Betina Kondisi Malnutrisi

• Main Authors: Erma, Safitri, Hernawati, Tatik, Utama, Suzanita, Sri, Mulyati, Legowo, Djoko
• Format: Article PeerReviewed
• Language: Indonesian; Indonesian
• Published: Fakultas Kedokteran Hewan Universitas airlangga 2012
• Subjects: SF405.5-407 Laboratory animals; SF811-909 Veterinary medicine of special organs, regions, and systems
• Online Access: http://repository.unair.ac.id/84641/2/Bukti%2014.%20Penurunan%20Estrus%20dan%20Gambaran%20....-min.pdf; http://repository.unair.ac.id/84641/1/Peer%20Review%20Bukti%2014.pdf; http://repository.unair.ac.id/84641/; http://journal.unair.ac.id/VETMED@oestrous-decrease-and-ovarian-histopathologic-description-of-female-mouse-(mus-article-6191-media-28-category-5.html
• Institution: Universitas Airlangga

This research was conducted with the long-term goal to improve the quality of livestock through scientific information on the bad effects and adverse effects of malnutrition for female animals. The specific target is to provide scientific information on the effects of malnutrition on reproductive dysfunction, infertiltas and sterility form the gonads (ovaries) in female mice as an animal model. The methods used are: females Mus musculus having malnutrition by fasting for 1, 2, 3, 4, and 5 days were given to drink ad libitum compared with controls fed a normal fixed 300-400 grams per day per mice and drinking water ad libitum. Further observations through several phases: 1. in vivo, based on an assessment of oestrous signs of the female, form female willingness to accept the stud marks (silent when riding), 2. the celluler, by histological examination of the preparation of the ovary organ, based on counting the number of Subordinate follicles (follicles secondary and tertiary), dominant follicle and corpus luteum and histopathological examination, and 3. in vitro by examination of vaginal smears 5 times of estrus cycle. Results from the study showed a significant difference between female mice made malnourished compared with controls, whereas in the treated mice led to a decline in malnutrition estrus signs (estrus) a decrease in the willingness of females accept males, dysfunction of folikulogenesis developmental processes such as the formation of the decline is not even subordinate follicles or dominant or persistent corpus luteum formation (CLP) and disorders of the reproductive cycle and histopathologic picture ovaries form of hyperemia, edema, and necrosis congesti. Keywords : Malnutrition, oestrous, FS, FD, CLP, ovarian histopathological