Increased Levels of Human 8 Defensinsin Childs with Dental Caries
Background: Human Beta Defensin peptide in saliva plays a role as innate immunity to dental caries. The purpose of this study is to determine whether peptide secretion of hBD1,2 and 3 saliva can be used as biological immune response to dental caries. Methods: Unstimulated whole saliva was collected...
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| Main Authors: | , , , , , |
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| Format: | Book Section PeerReviewed |
| Language: | English Indonesian English Indonesian |
| Published: |
Medical Devices and Technology Group
2017
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| Online Access: | http://repository.unair.ac.id/85331/1/P34_Increased-Levels-of-Human-%CE%92-Defensinsin-Childs-with-Dental-Caries_2.pdf http://repository.unair.ac.id/85331/2/Retno%20indra%204.pdf http://repository.unair.ac.id/85331/4/4.%20%20Increased-Levels-of-Human-_-Defensinsin-Childs-with-Dental-Caries.pdf http://repository.unair.ac.id/85331/5/Lutfi%2016%20%28Increased%29.pdf http://repository.unair.ac.id/85331/ http://www.utm.my/imeditec2017/files/2017/10/P34_Increased-Levels-of-Human-%CE%92-Defensinsin-Childs-with-Dental-Caries.pdf |
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| Institution: | Universitas Airlangga |
| Language: | English Indonesian English Indonesian |
| Summary: | Background: Human Beta Defensin peptide in saliva plays a role as innate immunity to dental caries. The purpose of this study is to determine whether peptide secretion of hBD1,2 and 3 saliva can be used as biological immune response to dental caries. Methods: Unstimulated whole saliva was collected for 55 elementary school students (6-10 years old) at Pondok Pesantren Qomaruddin Gresik, for levels of hBD1,2 and 3 were assessed by ELISA. Salivary pH was measured using digital pH meter. Results: The median hBD1, hBD2 and hBD3 saliva levels for the caries-free group (n = 22) were 0.86 μg / ml, 1.76 μg / ml and 1.88 μg / ml respectively and for the caries group (n = 33) were 5.26 μg / ml, 4.25 μg / ml and 4.85 μg / ml. The result proofs that the Levels of hBD1, hBD2 and hBD3 has a significant correlation with caries experience (p <0.01). The saliva pH in the caries group patient is also more acidic (6.0 - 6.5) than the caries-free group pH (6,9 - 7.0). Conclusion: From the results of this study it can be concluded that the high saliva levels secretion hBD1,2 and 3, can represent the immune response to dental caries and can be used as a new way to prevent dental caries and caries risk assessment |
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