Wild Type p53 Protein level and Micronuclei Number formed as a Biomarker Occupational Exposure of Metal in Dental Technicians in Surabaya

• Main Authors: Titiek Berniyanti, Retno Pudji Rahayu, Indah Listiana Kriswandini
• Format: Article PeerReviewed
• Language: English; English; Indonesian; Indonesian
• Published: Indonesian Center for Biodiversity and Biotechnology (ICBB) 2018
• Subjects: R Medicine; RK Dentistry
• Online Access: http://repository.unair.ac.id/86004/1/17-30-1-SM_2.pdf; http://repository.unair.ac.id/86004/4/WILD%20TYPE%20p53%20PROTEIN%20LEVEL%20AND%20MICRONUCLEI%20NUMBER%20FORMED%20AS%20A%20BIOMARKER%20OCCUPATIONAL%20EXPOSURE%20OF%20METAL%20IN%20DENTAL%20TECHNICIANS%20IN%20SURABAYA%281%29.pdf; http://repository.unair.ac.id/86004/6/10.titik%20validasi%20wild%20tipe%20p53.pdf; http://repository.unair.ac.id/86004/7/Di.Indah%20%28Wild%20Type%29.pdf; http://repository.unair.ac.id/86004/; http://journal.bioremediation-forum.org/index.php/jeb/about/contact
• Institution: Universitas Airlangga

Exposure of occupational metals (Co,Ni and Cr) lead to the formation of ROS, and cause damage to DNA. ROS also cause G-T transversion mutation of p53 gene, and lead to low expression of the wild type p53. Wild type p53 plays an important role in regulating genes in cell cycle, cell growth, and DNA r...