Penggunaan Antikanker Sari Buah Merah (Pandanus conoideus) Terhadap Kultur Sel Mieloma

• Main Authors: Rochmah Kurnijasanti, -, Reny I'tishom, -
• Format: Article PeerReviewed
• Language: Indonesian; English; Indonesian
• Published: Ikatan Ahli Ilmu Faal Indonesia (IAIFI) 2008
• Subjects: SF600-1100 Veterinary medicine; SF910 Other diseases and conditions
• Online Access: https://repository.unair.ac.id/86028/2/Bukti%20C%2004%20Penggunaan%20Anti%20Kanker%20Sari%20Buah%20Merah%20.....pdf; https://repository.unair.ac.id/86028/6/Peer%20Review%20Penggunaan%20Antikanker.pdf; https://repository.unair.ac.id/86028/4/04-Turnitin%2021%25%20Penggunaan%20Antikanker%20Sari%20Buah%20Merah%20%28Pandanus%20Conoideus%29%20Terhadap%20Kultur%20Sel%20Mieloma.pdf; https://repository.unair.ac.id/86028/; http://journal.unair.ac.id/[e-mail]
• Institution: Universitas Airlangga

The red fruit (Pandanus conoideus) has been reported as useful traditional anticancer agent but not scientifically proven. The aim of this study was to test the in vitro cytotoxic effect of the red fruit’s extract on cell culture of myeloma. The concentrations of red fruit extract used were 5, 2.5, 1.25, 0.625 and 0.312 mg/ml. Methanol was used as solution control in five different concentrations (10; 5; 2.5; 1.25; and 0.625) mg/ml while RPMI was used as negative control. The solution was added into the myeloma cell culture in microwell plate and incubated for 24 hours at 37ºC in CO2 incubator. The anticancer activity was determined using the viability of myeloma cell. The data showed that the extract of red fruit (Pandanus conoideus) has a weak anticancer activity when the extract caused significant (p<0.05) reduction in viability of myeloma cells compared to negative control. However, the positive control revealed a much more reduction in viability, significantly (p<0.05) less than the red fruit extract. The concentration of 5 mg/ml had been shown to kill 24.75% of myeloma cells Keywords: Anticancer, Pandanus conoideus, Myeloma