A potential therapy of human umbilical cord mesenchymal stem cells for bone regeneration on osteoporotic mandibular bone

• Main Authors: Nike Hendrijantini, NIDN. 0006105908, Tuti Kusumaningsih, NIDN. 0023105202, Rostiny, NIDN. 0020095402, Pungky Mulawardhana, COEN PRAMONO DANUDININGRAT, 195402101979011001, Fedik Abdul Rantam, NIDN. 0010035907
• Format: Article PeerReviewed
• Language: English; English; English
• Published: Dental Investigations Surgery 2018
• Subjects: R Medicine; RK Dentistry
• Online Access: http://repository.unair.ac.id/87136/1/NIKE%203.pdf; http://repository.unair.ac.id/87136/3/3.%20A%20potential%20therapy%20of%20human%20umbilical%20cord%20mesenchymal%20stem%20cells%20for%20bone%20regeneration%20on%20osteoporotic%20mandibular%20bone.pdf; http://repository.unair.ac.id/87136/6/per%20nike%203.3.pdf; http://repository.unair.ac.id/87136/; http://www.eurjdent.com/article.asp?issn=1305-7456;year=2018;volume=12;issue=3;spage=358;epage=362;aulast=Hendrijantini
• Institution: Universitas Airlangga

Objective: The aim of this study is to prove that human umbilical cord mesenchymal stem cell (hUCMSC) therapy on mandibular osteoporotic model is able to increase transforming growth factor‑beta‑1 (TGF)‑β1 expression, Runx2, and osteoblasts. Materials and Methods: This research is true experimental posttest control group design. Thirty female Wistar rats were divided into 6 groups randomly, which consisted of sham surgery for control (T1), ovariectomy as osteoporotic group (T2), osteoporotic group injected with gelatine for 4 weeks (T3), 8 weeks (T4) injected with hUCMSC‑gelatine for 4 weeks (T5) and 8 weeks (T6). All mice were presented for immunohistochemistry examination for TGF‑β1, Runx2, and histology for osteoblasts. Results: The lowest level of osteoblast was osteoporotic group injected with gelatine in 4 weeks compared to other groups. There were increases of TGF‑β1, Runx2, and osteoblasts from osteoporotic group compared to osteoporotic post‑hUCMSC‑gelatine injection group. Conclusion: The hUCMSC has a high osteogenic effect and increases the osteoporotic mandibular bone regeneration on the animal model that is showed by the increase of the level of TGF‑β1, Runx2, and osteoblasts