ANALISIS KORELASI KADAR ESTRADIOL URINE DAN SERUM DAN KONTRIBUSINYA TERHADAP DIAGNOSA KEMATANGAN FOLIKEL PASIEN IN VITRO FERTILIZATION DENGAN TERAPI CONTROLLED OVARIAN HYPERSTIMULATION

• Main Author: ARROOFITA ANI SANDIYA, 051614153009
• Format: Theses and Dissertations NonPeerReviewed
• Language: Indonesian; Indonesian; Indonesian; Indonesian
• Published: 2019
• Subjects: RM300-666 Drugs and their actions
• Online Access: http://repository.unair.ac.id/88693/1/TF.%2015-19%20San%20a%20abstrak.pdf; http://repository.unair.ac.id/88693/2/TF.%2015-19%20San%20a%20daftar%20isi.pdf; http://repository.unair.ac.id/88693/3/TF.%2015-19%20San%20a%20daftar%20pustaka.pdf; http://repository.unair.ac.id/88693/4/TF.%2015-19%20San%20a.pdf; http://repository.unair.ac.id/88693/; http://lib.unair.ac.id
• Institution: Universitas Airlangga

Background: One of the stages in the In Vitro Fertilization technique is the prospective mother will be given hormonal drugs as a trigger for ovulation to produce many eggs. This stage is called ovarian stimulation or Controlled Ovarian Hyperstimulation (COH). Durineg the menstrual cycle stimulated by the COH procedure, blood steroid hormone levels increase as a result of the development of multiple ovarian follicles. In hormone ecretion, the hormone will experience conjugation with sulfate or glucoronide derivatives to become hydrophilic compounds, then eventually it will be secreted through urine or feces. Objective: : This study aims to determine estrogen levels in urine in patients with ovarian stimulation therapy. Performed on 40 women and urine samples of patients Materials and Methods: This study were analyzed by ELISA. Results: The analysis of estradiol levels in urine and serum samples showed that the average urineary estradiol levels before COH therapy with urineary estradiol levels after COH therapy yielded 16,650 ng / L ± 5,767 and 16,517 ng / L ± 5,617 respectively. Mature follicles are characterized by follicular diameters reaching> 16 mm with a minimum number of 3 follicles. In this study the correlation coefficient value of urineary estradiol with the number of mature follicles was obtained. The results of the correlation coefficient were -0.223 and the significance value (2-tailed) of 0.204> 0.05. Conclutions: In this study it can be concluded that there is no correlation between estradiol levels before COH and after COH in urine samples, and estradiol levels in urine samples are not able to describe the level of follicular maturity.