ANALISIS KORELASI KADAR ESTRADIOL URINE DAN SERUM DAN KONTRIBUSINYA TERHADAP DIAGNOSA KEMATANGAN FOLIKEL PASIEN IN VITRO FERTILIZATION DENGAN TERAPI CONTROLLED OVARIAN HYPERSTIMULATION
Background: One of the stages in the In Vitro Fertilization technique is the prospective mother will be given hormonal drugs as a trigger for ovulation to produce many eggs. This stage is called ovarian stimulation or Controlled Ovarian Hyperstimulation (COH). Durineg the menstrual cycle stimulat...
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Format: | Theses and Dissertations NonPeerReviewed |
Language: | Indonesian Indonesian Indonesian Indonesian |
Published: |
2019
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Subjects: | |
Online Access: | http://repository.unair.ac.id/88693/1/TF.%2015-19%20San%20a%20abstrak.pdf http://repository.unair.ac.id/88693/2/TF.%2015-19%20San%20a%20daftar%20isi.pdf http://repository.unair.ac.id/88693/3/TF.%2015-19%20San%20a%20daftar%20pustaka.pdf http://repository.unair.ac.id/88693/4/TF.%2015-19%20San%20a.pdf http://repository.unair.ac.id/88693/ http://lib.unair.ac.id |
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Institution: | Universitas Airlangga |
Language: | Indonesian Indonesian Indonesian Indonesian |
Summary: | Background: One of the stages in the In Vitro Fertilization technique is the
prospective mother will be given hormonal drugs as a trigger for ovulation to
produce many eggs. This stage is called ovarian stimulation or Controlled Ovarian
Hyperstimulation (COH). Durineg the menstrual cycle stimulated by the COH
procedure, blood steroid hormone levels increase as a result of the development of
multiple ovarian follicles. In hormone ecretion, the hormone will experience
conjugation with sulfate or glucoronide derivatives to become hydrophilic
compounds, then eventually it will be secreted through urine or feces.
Objective: : This study aims to determine estrogen levels in urine in patients with
ovarian stimulation therapy. Performed on 40 women and urine samples of patients
Materials and Methods: This study were analyzed by ELISA.
Results: The analysis of estradiol levels in urine and serum samples showed that
the average urineary estradiol levels before COH therapy with urineary estradiol
levels after COH therapy yielded 16,650 ng / L ± 5,767 and 16,517 ng / L ± 5,617
respectively. Mature follicles are characterized by follicular diameters reaching>
16 mm with a minimum number of 3 follicles. In this study the correlation
coefficient value of urineary estradiol with the number of mature follicles was
obtained. The results of the correlation coefficient were -0.223 and the significance
value (2-tailed) of 0.204> 0.05.
Conclutions: In this study it can be concluded that there is no correlation between
estradiol levels before COH and after COH in urine samples, and estradiol levels in
urine samples are not able to describe the level of follicular maturity. |
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